Tbio CPE Carboxypeptidase E

Protein Summary

Description

Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin. This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P16870
• A8K4N1
• B3KR42
• B4DFN4
• D3DP33
• Q9UIU9
• CPE

Gene Name

• CPE

Ensembl ID

• ENST00000402744
• ENSP00000386104
• ENSG00000109472

Symbol

• CPH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.97
transcription factor perturbation	0.96
gene perturbation	0.9
cellular component	0.84
phenotype	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 496.63   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 318   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 496.63   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (89)

Explore Interacting Targets

1 – 10 of 89

• See Interactions on String-DB

FAM19A2

Tbio

Novelty:  0.28999346

p_int:  0.999887694

p_ni:  0.000112298

p_wrong:  7e-9

Data Source:  BioPlex

DHFR2

Tbio

Family:  Enzyme

Novelty:  0.02374466

p_int:  0.999662181

p_ni:  0.000337815

p_wrong:  4e-9

Data Source:  BioPlex

CSTL1

Tbio

Novelty:  0.13370814

p_int:  0.998013322

p_ni:  0.001984739

p_wrong:  0.000001939

Data Source:  BioPlex

HYOU1

Tbio

Novelty:  0.00833649

p_int:  0.997926495

p_ni:  0.001797223

p_wrong:  0.000276282

Data Source:  BioPlex

PSG8

Tdark

Novelty:  0.1446257

p_int:  0.997396488

p_ni:  0.002581693

p_wrong:  0.000021819

Score:  0.201

Data Source:  BioPlex,STRINGDB

SERPINB11

Tbio

Novelty:  0.09937169

p_int:  0.996384822

p_ni:  0.003612848

p_wrong:  0.000002331

Score:  0.265

Data Source:  BioPlex,STRINGDB

RLN1

Tbio

Novelty:  0.03992636

p_int:  0.994386262

p_ni:  0.005571656

p_wrong:  0.000042082

Data Source:  BioPlex

SIAE

Tbio

Family:  Enzyme

Novelty:  0.01138067

p_int:  0.994142899

p_ni:  0.005839606

p_wrong:  0.000017495

Data Source:  BioPlex

SLAMF1

Tbio

Novelty:  0.00112892

p_int:  0.993809087

p_ni:  0.006189576

p_wrong:  0.000001337

Score:  0.175

Data Source:  BioPlex,STRINGDB

B3GALT5

Tbio

Family:  Enzyme

Novelty:  0.04158039

p_int:  0.993142372

p_ni:  0.006749498

p_wrong:  0.00010813

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (3)

KEGG (1)

PathwayCommons (3)

Insulin processing (R-HSA-264876)

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Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Insulin processing	27 targets	R-HSA-264876
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Peptide hormone metabolism	88 targets	R-HSA-2980736

Name	Explore in Pharos	Explore in Source
Insulin processing	27 targets	R-HSA-264876
Metabolism of proteins	2050 targets	R-HSA-392499
Peptide hormone metabolism	88 targets	R-HSA-2980736

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (22)

Functions (5)

Components (9)

Processes (8)

Find Similar Targets

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1 – 5 of 5

GO Term	Evidence	Assigned by
cell adhesion molecule binding	Inferred from Physical Interaction (IPI)	BHF-UCL
neurexin family protein binding	Inferred from Physical Interaction (IPI)	BHF-UCL
metallocarboxypeptidase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
carboxypeptidase activity	Traceable Author Statement (TAS)	ProtInc
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	2	2		66.2
insulin measurement	EFO_0004467	1	1	2		21.5
intelligence	EFO_0004337	1	1	0	5.6	17.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2		66.2
insulin measurement	EFO_0004467	2		21.5
intelligence	EFO_0004337	0	5.6	17.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Carboxypeptidase
Cleavage on pair of basic residues
Complete proteome
Cytoplasmic vesicle
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease

GWAS Trait Find Similar Targets

No Header	No Header
heel bone mineral density
insulin measurement
intelligence

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
liver/biliary system phenotype
muscle phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	carboxypeptidase E	VGNC:10850	461592
Macaque	carboxypeptidase E		708881
Mouse	carboxypeptidase E	MGI:101932	12876
Rat	carboxypeptidase E	RGD:2394	25669
Dog	carboxypeptidase E	VGNC:39552	475492

Species	Name	OMA	EggNOG	Inparanoid
Chimp	carboxypeptidase E
Macaque	carboxypeptidase E
Mouse	carboxypeptidase E
Rat	carboxypeptidase E
Dog	carboxypeptidase E

Publication Statistics

PubMed Score 496.63

PubMed score by year

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PubTator Score 270.33

PubTator score by year

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Related Publications

Text Mined References (64)

GeneRif Annotations (32)

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PMID	Year	Title