Protein Summary
Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin. This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
- ENST00000402744
- ENSP00000386104
- ENSG00000109472
- CPH
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.97 | ||
transcription factor perturbation | 0.96 | ||
gene perturbation | 0.9 | ||
cellular component | 0.84 | ||
phenotype | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 496.63 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 318 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 496.63 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 318 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (89)
FAM19A2
Novelty: 0.28999346
p_int: 0.999887694
p_ni: 0.000112298
p_wrong: 7e-9
Data Source: BioPlex
DHFR2
Family: Enzyme
Novelty: 0.02374466
p_int: 0.999662181
p_ni: 0.000337815
p_wrong: 4e-9
Data Source: BioPlex
CSTL1
Novelty: 0.13370814
p_int: 0.998013322
p_ni: 0.001984739
p_wrong: 0.000001939
Data Source: BioPlex
HYOU1
Novelty: 0.00833649
p_int: 0.997926495
p_ni: 0.001797223
p_wrong: 0.000276282
Data Source: BioPlex
PSG8
Novelty: 0.1446257
p_int: 0.997396488
p_ni: 0.002581693
p_wrong: 0.000021819
Score: 0.201
Data Source: BioPlex,STRINGDB
SERPINB11
Novelty: 0.09937169
p_int: 0.996384822
p_ni: 0.003612848
p_wrong: 0.000002331
Score: 0.265
Data Source: BioPlex,STRINGDB
RLN1
Novelty: 0.03992636
p_int: 0.994386262
p_ni: 0.005571656
p_wrong: 0.000042082
Data Source: BioPlex
SIAE
Family: Enzyme
Novelty: 0.01138067
p_int: 0.994142899
p_ni: 0.005839606
p_wrong: 0.000017495
Data Source: BioPlex
SLAMF1
Novelty: 0.00112892
p_int: 0.993809087
p_ni: 0.006189576
p_wrong: 0.000001337
Score: 0.175
Data Source: BioPlex,STRINGDB
B3GALT5
Family: Enzyme
Novelty: 0.04158039
p_int: 0.993142372
p_ni: 0.006749498
p_wrong: 0.00010813
Data Source: BioPlex
Nearest Tclin Targets
Pathways (7)
Reactome (3)
KEGG (1)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Insulin processing | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Peptide hormone metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Insulin processing | ||||
Metabolism of proteins | ||||
Peptide hormone metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (5)
Components (9)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 2 | 2 | 66.2 | |||||
insulin measurement | 1 | 1 | 2 | 21.5 | |||||
intelligence | 1 | 1 | 0 | 5.6 | 17.8 | ||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 66.2 | |||||
insulin measurement | 2 | 21.5 | |||||
intelligence | 0 | 5.6 | 17.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | carboxypeptidase E | VGNC:10850 | 461592 | |||||
Macaque | carboxypeptidase E | 708881 | ||||||
Mouse | MGI:101932 | 12876 | ||||||
Rat | RGD:2394 | 25669 | ||||||
Dog | carboxypeptidase E | VGNC:39552 | 475492 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | carboxypeptidase E | |||||
Macaque | carboxypeptidase E | |||||
Mouse | ||||||
Rat | ||||||
Dog | carboxypeptidase E | |||||
Publication Statistics
PubMed Score 496.63
PubMed score by year
PubTator Score 270.33
PubTator score by year
Related Publications
Text Mined References (64)
GeneRif Annotations (32)
Items per page:
0 of 0
PMID | Year | Title |
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