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Tbio
CPE
Carboxypeptidase E

Protein Summary
Description
Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin. This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402744
  • ENSP00000386104
  • ENSG00000109472

Symbol
  • CPH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
transcription factor perturbation
0.96
gene perturbation
0.9
cellular component
0.84
phenotype
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 496.63   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 318   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 496.63   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
FAM19A2
Tbio
Novelty:  0.28999346
p_int:  0.999887694
p_ni:  0.000112298
p_wrong:  7e-9
Data Source:  BioPlex
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.999662181
p_ni:  0.000337815
p_wrong:  4e-9
Data Source:  BioPlex
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.998013322
p_ni:  0.001984739
p_wrong:  0.000001939
Data Source:  BioPlex
HYOU1
Tbio
Novelty:  0.00833649
p_int:  0.997926495
p_ni:  0.001797223
p_wrong:  0.000276282
Data Source:  BioPlex
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.997396488
p_ni:  0.002581693
p_wrong:  0.000021819
Score:  0.201
Data Source:  BioPlex,STRINGDB
SERPINB11
Tbio
Novelty:  0.09937169
p_int:  0.996384822
p_ni:  0.003612848
p_wrong:  0.000002331
Score:  0.265
Data Source:  BioPlex,STRINGDB
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.994386262
p_ni:  0.005571656
p_wrong:  0.000042082
Data Source:  BioPlex
SIAE
Tbio
Family:  Enzyme
Novelty:  0.01138067
p_int:  0.994142899
p_ni:  0.005839606
p_wrong:  0.000017495
Data Source:  BioPlex
SLAMF1
Tbio
Novelty:  0.00112892
p_int:  0.993809087
p_ni:  0.006189576
p_wrong:  0.000001337
Score:  0.175
Data Source:  BioPlex,STRINGDB
B3GALT5
Tbio
Family:  Enzyme
Novelty:  0.04158039
p_int:  0.993142372
p_ni:  0.006749498
p_wrong:  0.00010813
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Insulin processing (R-HSA-264876)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin processing
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Insulin processing
Metabolism of proteins
Peptide hormone metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
66.2
insulin measurement
1
1
2
21.5
intelligence
1
1
0
5.6
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
66.2
insulin measurement
2
21.5
intelligence
0
5.6
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase E
VGNC:10850
461592
Macaque
carboxypeptidase E
708881
Mouse
MGI:101932
12876
Rat
RGD:2394
25669
Dog
carboxypeptidase E
VGNC:39552
475492
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase E
Macaque
carboxypeptidase E
Mouse
Rat
Dog
carboxypeptidase E
Publication Statistics
PubMed Score 496.63
PubMed score by year
PubTator Score 270.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title