Tbio CPD Carboxypeptidase D

Protein Summary

Description

The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75976
• B7Z7T9
• B7ZAU4
• F5GZH6
• O15377
• Q86SH9
• Q86XE6

Gene Name

• CPD

Ensembl ID

• ENST00000225719
• ENSP00000225719
• ENSG00000108582
• ENST00000543464
• ENSP00000444443

Symbol

• GP180

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
PubMedID	0.87
microRNA	0.85
disease perturbation	0.74
transcription factor binding site profile	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.76   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 92   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.76   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0