Tchem CPB1 Carboxypeptidase B

Protein Summary

Description

Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15086
• O60834
• Q53XJ0
• Q96BQ8

Gene Name

• CPB1

Ensembl ID

• ENST00000282957
• ENSP00000282957
• ENSG00000153002
• ENST00000491148
• ENSP00000417222

Symbol

• CPB
• PCPB
• CPB
• PASP
• PCPB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.68
PubMedID	0.61
small molecule perturbation	0.59
tissue sample	0.58
cell line	0.57

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / Carboxypeptidase B

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Carboxypeptidase B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1130.57   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 316   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1130.57   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 36

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0