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Tbio
CPAMD8
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8

Protein Summary
Description
This gene encodes a member of the protease inhibitor I39 (alpha-2-macroglobulin) family of proteins. These proteins are important in innate and acquired immunity. The encoded protein is membrane-associated and proteolytically processed to generate two chains. Mutations in this gene cause a form of anterior segment dysgenesis, a developmental disorder of the eye. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291440
  • ENSP00000291440
  • ENSG00000160111
  • ENST00000443236
  • ENSP00000402505

Symbol
  • KIAA1283
  • VIP
  • ASGD8
  • K-CAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
cell line
0.63
tissue sample
0.63
trait
0.46
phenotype
0.44


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0