Pharos : Target Details

Tbio

Protein Summary

Description

May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II (PubMed:18178555). Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine (PubMed:20855895). The gene encodes a member of the peptidase M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which catalyzes the release of large hydrophobic C-terminal amino acids. This enzyme has functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Mutations in this gene may be linked to epilepsy and febrile seizures, and a translocation t(6;8)(q26;q13) involving this gene has been associated with Duane retraction syndrome. [provided by RefSeq, May 2016]

Uniprot Accession IDs

Gene Name

CPA6

Ensembl ID

ENST00000297770
ENSP00000297770
ENSG00000165078
ENST00000479862
ENSP00000419016
ENST00000638254
ENSP00000491129

Symbol

CPAH
CPAH
ETL5
FEB11

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91

trait	0.75

cell type or tissue	0.57

molecular function	0.56

tissue	0.56

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.26 (req: < 5)

View Publications

Gene RIFs: 12 (req: <= 3)

View Gene RIFs

Antibodies: 157 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.26 (req: >= 5)

Gene RIFs: 12 (req: > 3)

Antibodies: 157 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (34)

Explore Interacting Targets

1 – 10 of 34

See Interactions on String-DB

FBXO15

Tbio

Novelty: 0.08562497

p_int: 0.999770249

p_ni: 0.000012594

p_wrong: 0.000217157

Score: 0.537

Data Source: BioPlex,STRINGDB

ZZEF1

Tdark

Novelty: 0.33216648

p_int: 0.996136964

p_ni: 0.003863035

Data Source: BioPlex

AMER1

Tbio

Novelty: 0.00951499

p_int: 0.98881628

p_ni: 0.0111824

p_wrong: 0.00000132

Score: 0.173

Data Source: BioPlex,STRINGDB

DICER1

Tbio

Family: Enzyme

Novelty: 0.000306

p_int: 0.981268707

p_ni: 0.018731279

p_wrong: 1.3e-8

Score: 0.174

Data Source: BioPlex,STRINGDB

UBB

Tbio

Novelty: 0.00661254

p_int: 0.963200689

p_ni: 0.036799311

Data Source: BioPlex

PPM1G

Tbio

Family: Enzyme

Novelty: 0.02646519

p_int: 0.9546897

p_ni: 0.0453103

Score: 0.19

Data Source: BioPlex,STRINGDB

FNTB

Tclin

Family: Enzyme

Novelty: 0.07434994

p_int: 0.938527841

p_ni: 0.061472158

Data Source: BioPlex

HECTD3

Tdark

Family: Enzyme

Novelty: 2.20874654

p_int: 0.917017993

p_ni: 0.082982007

Data Source: BioPlex

TARBP2

Tbio

Novelty: 0.01485994

p_int: 0.910120432

p_ni: 0.089879567

p_wrong: 1e-9

Data Source: BioPlex

FUT11

Tbio

Family: Enzyme

Novelty: 0.16098097

p_int: 0.896727981

p_ni: 0.09557694

p_wrong: 0.007695079

Data Source: BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (2)

Components (1)

Processes (1)

Find Similar Targets

Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
metallocarboxypeptidase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword

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No Header	No Header
Alternative splicing

Carboxypeptidase

Chromosomal rearrangement

Cleavage on pair of basic residues

Complete proteome

Disease mutation

Disulfide bond

Epilepsy

Extracellular matrix

Glycoprotein

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID
Chimp	carboxypeptidase A6	VGNC:902	472786

Macaque	carboxypeptidase A6		705117

Mouse	carboxypeptidase A6	MGI:3045348	329093

Rat	carboxypeptidase A6	RGD:1311764	312913

Dog	carboxypeptidase A6	VGNC:39547	486983

Species	Name	OMA	EggNOG	Inparanoid
Chimp	carboxypeptidase A6

Macaque	carboxypeptidase A6

Mouse	carboxypeptidase A6

Rat	carboxypeptidase A6

Dog	carboxypeptidase A6

Publication Statistics

PubMed Score 24.26

PubMed score by year

PubTator Score 70.27

PubTator score by year

Related Publications

Text Mined References (19)

GeneRif Annotations (12)

Items per page:

0 of 0

PMID	Year	Title