You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CPA6
Carboxypeptidase A6

Protein Summary
Description
May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II (PubMed:18178555). Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine (PubMed:20855895). The gene encodes a member of the peptidase M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which catalyzes the release of large hydrophobic C-terminal amino acids. This enzyme has functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Mutations in this gene may be linked to epilepsy and febrile seizures, and a translocation t(6;8)(q26;q13) involving this gene has been associated with Duane retraction syndrome. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297770
  • ENSP00000297770
  • ENSG00000165078
  • ENST00000479862
  • ENSP00000419016
  • ENST00000638254
  • ENSP00000491129

Symbol
  • CPAH
  • CPAH
  • ETL5
  • FEB11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
trait
0.75
cell type or tissue
0.57
molecular function
0.56
tissue
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.26   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.26   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
FBXO15
Tbio
Novelty:  0.08562497
p_int:  0.999770249
p_ni:  0.000012594
p_wrong:  0.000217157
Score:  0.537
Data Source:  BioPlex,STRINGDB
ZZEF1
Tdark
Novelty:  0.33216648
p_int:  0.996136964
p_ni:  0.003863035
Data Source:  BioPlex
AMER1
Tbio
Novelty:  0.00951499
p_int:  0.98881628
p_ni:  0.0111824
p_wrong:  0.00000132
Score:  0.173
Data Source:  BioPlex,STRINGDB
DICER1
Tbio
Family:  Enzyme
Novelty:  0.000306
p_int:  0.981268707
p_ni:  0.018731279
p_wrong:  1.3e-8
Score:  0.174
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.963200689
p_ni:  0.036799311
Data Source:  BioPlex
PPM1G
Tbio
Family:  Enzyme
Novelty:  0.02646519
p_int:  0.9546897
p_ni:  0.0453103
Score:  0.19
Data Source:  BioPlex,STRINGDB
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.938527841
p_ni:  0.061472158
Data Source:  BioPlex
HECTD3
Tdark
Family:  Enzyme
Novelty:  2.20874654
p_int:  0.917017993
p_ni:  0.082982007
Data Source:  BioPlex
TARBP2
Tbio
Novelty:  0.01485994
p_int:  0.910120432
p_ni:  0.089879567
p_wrong:  1e-9
Data Source:  BioPlex
FUT11
Tbio
Family:  Enzyme
Novelty:  0.16098097
p_int:  0.896727981
p_ni:  0.09557694
p_wrong:  0.007695079
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase A6
VGNC:902
472786
Macaque
carboxypeptidase A6
705117
Mouse
MGI:3045348
329093
Rat
RGD:1311764
312913
Dog
carboxypeptidase A6
VGNC:39547
486983
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase A6
Macaque
carboxypeptidase A6
Mouse
Rat
Dog
carboxypeptidase A6
Publication Statistics
PubMed Score 24.26
PubMed score by year
PubTator Score 70.27
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title