Tbio CPA6 Carboxypeptidase A6

Protein Summary

Description

May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II (PubMed:18178555). Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine (PubMed:20855895). The gene encodes a member of the peptidase M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which catalyzes the release of large hydrophobic C-terminal amino acids. This enzyme has functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Mutations in this gene may be linked to epilepsy and febrile seizures, and a translocation t(6;8)(q26;q13) involving this gene has been associated with Duane retraction syndrome. [provided by RefSeq, May 2016]

Uniprot Accession IDs

• Q8N4T0
• Q8NEX8
• Q8TDE8
• Q9NRI9

Gene Name

• CPA6

Ensembl ID

• ENST00000297770
• ENSP00000297770
• ENSG00000165078
• ENST00000479862
• ENSP00000419016
• ENST00000638254
• ENSP00000491129

Symbol

• CPAH
• CPAH
• ETL5
• FEB11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
trait	0.75
cell type or tissue	0.57
molecular function	0.56
tissue	0.56

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / Carboxypeptidase A6

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Carboxypeptidase A6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.22   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.22   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0