Protein Summary
Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]
- ENST00000393213
- ENSP00000376907
- ENSG00000158525
- ENST00000431780
- ENSP00000393045
- ENST00000461828
- ENSP00000418183
- ENST00000466363
- ENSP00000419025
- ENST00000474905
- ENSP00000417314
- ENST00000485477
- ENSP00000420237
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.71 | ||
molecular function | 0.56 | ||
cell type or tissue | 0.49 | ||
tissue | 0.49 | ||
metabolite | 0.45 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.83 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 84 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.83 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 84 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (45)
POTEE
Novelty: 0.29349205
p_int: 0.999994489
p_ni: 0.000005509
p_wrong: 1e-9
Score: 0.157
Data Source: BioPlex,STRINGDB
EPHA4
Family: Kinase
Novelty: 0.00321698
p_int: 0.992916647
p_ni: 0.007083353
Data Source: BioPlex
MPZL1
Novelty: 0.03292508
p_int: 0.925746916
p_ni: 0.074252655
p_wrong: 4.3e-7
Data Source: BioPlex
HSPA5
Novelty: 0.00043424
p_int: 0.922404892
p_ni: 0.077595108
Score: 0.174
Data Source: BioPlex,STRINGDB
NME4
Family: Kinase
Novelty: 0.03735196
p_int: 0.896195858
p_ni: 0.103804016
p_wrong: 1.26e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
SPG7
Family: Enzyme
Novelty: 0.00463357
p_int: 0.878983469
p_ni: 0.121016512
p_wrong: 1.9e-8
Score: 0.215
Data Source: BioPlex,STRINGDB
GAS6
Novelty: 0.00297606
p_int: 0.86194326
p_ni: 0.131321042
p_wrong: 0.006735698
Data Source: BioPlex
SVIP
Novelty: 0.05269453
p_int: 0.840621539
p_ni: 0.08248426
p_wrong: 0.076894201
Score: 0.161
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (2)
Components (1)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hip circumference | 1 | 11 | 11 | 90.9 | |||||
BMI-adjusted hip circumference | 1 | 7 | 7 | 83.3 | |||||
waist circumference | 1 | 6 | 6 | 80.3 | |||||
BMI-adjusted waist circumference | 2 | 7 | 7 | 77.9 | |||||
waist-hip ratio | 1 | 2 | 2 | 37.3 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hip circumference | 11 | 90.9 | |||||
BMI-adjusted hip circumference | 7 | 83.3 | |||||
waist circumference | 6 | 80.3 | |||||
BMI-adjusted waist circumference | 7 | 77.9 | |||||
waist-hip ratio | 2 | 37.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | carboxypeptidase A5 | 702974 | ||||||
Mouse | MGI:1921899 | 74649 | ||||||
Rat | RGD:1303098 | 408212 | ||||||
Dog | carboxypeptidase A5 | VGNC:39546 | 482257 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | carboxypeptidase A5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | carboxypeptidase A5 | |||||
Publication Statistics
PubMed Score 19.83
PubMed score by year
PubTator Score 12.40
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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