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Tbio
CPA5
Carboxypeptidase A5

Protein Summary
Description
Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393213
  • ENSP00000376907
  • ENSG00000158525
  • ENST00000431780
  • ENSP00000393045
  • ENST00000461828
  • ENSP00000418183
  • ENST00000466363
  • ENSP00000419025
  • ENST00000474905
  • ENSP00000417314
  • ENST00000485477
  • ENSP00000420237
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
molecular function
0.56
cell type or tissue
0.49
tissue
0.49
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.83   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.83   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
POTEE
Tbio
Novelty:  0.29349205
p_int:  0.999994489
p_ni:  0.000005509
p_wrong:  1e-9
Score:  0.157
Data Source:  BioPlex,STRINGDB
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
p_int:  0.992916647
p_ni:  0.007083353
Data Source:  BioPlex
KIRREL1
Tbio
Novelty:  0.03216031
p_int:  0.958308755
p_ni:  0.041691245
Data Source:  BioPlex
MPZL1
Tbio
Novelty:  0.03292508
p_int:  0.925746916
p_ni:  0.074252655
p_wrong:  4.3e-7
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.922404892
p_ni:  0.077595108
Score:  0.174
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.91137113
p_ni:  0.08862887
Data Source:  BioPlex
NME4
Tbio
Family:  Kinase
Novelty:  0.03735196
p_int:  0.896195858
p_ni:  0.103804016
p_wrong:  1.26e-7
Score:  0.199
Data Source:  BioPlex,STRINGDB
SPG7
Tbio
Family:  Enzyme
Novelty:  0.00463357
p_int:  0.878983469
p_ni:  0.121016512
p_wrong:  1.9e-8
Score:  0.215
Data Source:  BioPlex,STRINGDB
GAS6
Tbio
Novelty:  0.00297606
p_int:  0.86194326
p_ni:  0.131321042
p_wrong:  0.006735698
Data Source:  BioPlex
SVIP
Tbio
Novelty:  0.05269453
p_int:  0.840621539
p_ni:  0.08248426
p_wrong:  0.076894201
Score:  0.161
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
1
11
11
90.9
BMI-adjusted hip circumference
1
7
7
83.3
waist circumference
1
6
6
80.3
BMI-adjusted waist circumference
2
7
7
77.9
waist-hip ratio
1
2
2
37.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
11
90.9
BMI-adjusted hip circumference
7
83.3
waist circumference
6
80.3
BMI-adjusted waist circumference
7
77.9
waist-hip ratio
2
37.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
carboxypeptidase A5
702974
Mouse
MGI:1921899
74649
Rat
RGD:1303098
408212
Dog
carboxypeptidase A5
VGNC:39546
482257
Species
Name
OMA
EggNOG
Inparanoid
Macaque
carboxypeptidase A5
Mouse
Rat
Dog
carboxypeptidase A5
Publication Statistics
PubMed Score 19.83
PubMed score by year
PubTator Score 12.40
PubTator score by year
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Related Publications
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PMID
Year
Title