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Tchem
CPA4
Carboxypeptidase A4

Protein Summary
Description
Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222482
  • ENSP00000222482
  • ENSG00000128510
  • ENST00000445470
  • ENSP00000412947
  • ENST00000647977
  • ENSP00000497118

Symbol
  • CPA3
  • CPA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
small molecule perturbation
0.58
molecular function
0.56
tissue sample
0.51
microRNA
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.37   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.37   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (71)
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.999157201
p_ni:  0.000842799
Data Source:  BioPlex
AIRE
Tbio
Family:  TF; Epigenetic
Novelty:  0.00158659
p_int:  0.989757993
p_ni:  0.010242007
Data Source:  BioPlex
FTH1
Tbio
Novelty:  0.000863
p_int:  0.989033715
p_ni:  0.010965798
p_wrong:  4.88e-7
Data Source:  BioPlex
CFAP298
Tbio
Novelty:  0.1550579
p_int:  0.974151159
p_ni:  0.025841285
p_wrong:  0.000007555
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.968718331
p_ni:  0.031281644
p_wrong:  2.5e-8
Data Source:  BioPlex
NDUFS5
Tclin
Family:  Enzyme
Novelty:  0.13274675
p_int:  0.967894528
p_ni:  0.03210058
p_wrong:  0.000004892
Data Source:  BioPlex
RAB9B
Tbio
Family:  Enzyme
Novelty:  0.19952686
p_int:  0.964171657
p_ni:  0.035828245
p_wrong:  9.8e-8
Data Source:  BioPlex
UBAC2
Tbio
Novelty:  0.13384376
p_int:  0.960323525
p_ni:  0.039676406
p_wrong:  6.9e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.957657989
p_ni:  0.042342011
Data Source:  BioPlex
SLCO6A1
Tbio
Family:  Transporter
Novelty:  0.07836028
p_int:  0.940958679
p_ni:  0.059041321
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
1
11
11
90.9
BMI-adjusted hip circumference
1
7
7
83.3
waist circumference
1
6
6
80.3
BMI-adjusted waist circumference
2
7
7
77.9
waist-hip ratio
1
2
2
37.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
11
90.9
BMI-adjusted hip circumference
7
83.3
waist circumference
6
80.3
BMI-adjusted waist circumference
7
77.9
waist-hip ratio
2
37.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase A4
VGNC:4318
463727
Macaque
carboxypeptidase A4
702856
Mouse
MGI:1919041
71791
Rat
RGD:1563619
502736
Dog
carboxypeptidase A4
VGNC:39545
482258
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase A4
Macaque
carboxypeptidase A4
Mouse
Rat
Dog
carboxypeptidase A4
Publication Statistics
PubMed Score 75.37
PubMed score by year
PubTator Score 18.46
PubTator score by year
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Related Publications
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PMID
Year
Title