Protein Summary
Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]
- ENST00000222482
- ENSP00000222482
- ENSG00000128510
- ENST00000445470
- ENSP00000412947
- ENST00000647977
- ENSP00000497118
- CPA3
- CPA3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.94 | ||
small molecule perturbation | 0.58 | ||
molecular function | 0.56 | ||
tissue sample | 0.51 | ||
microRNA | 0.44 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 97.08 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 76 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 97.08 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 76 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 11
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (11)
Protein-Protein Interactions (71)
AIRE
Family: TF; Epigenetic
Novelty: 0.00158659
p_int: 0.989757993
p_ni: 0.010242007
Data Source: BioPlex
FTH1
Novelty: 0.000863
p_int: 0.989033715
p_ni: 0.010965798
p_wrong: 4.88e-7
Data Source: BioPlex
CFAP298
Novelty: 0.1550579
p_int: 0.974151159
p_ni: 0.025841285
p_wrong: 0.000007555
Data Source: BioPlex
TBC1D22B
Novelty: 0.49852962
p_int: 0.968718331
p_ni: 0.031281644
p_wrong: 2.5e-8
Data Source: BioPlex
NDUFS5
Family: Enzyme
Novelty: 0.13274675
p_int: 0.967894528
p_ni: 0.03210058
p_wrong: 0.000004892
Data Source: BioPlex
RAB9B
Family: Enzyme
Novelty: 0.19952686
p_int: 0.964171657
p_ni: 0.035828245
p_wrong: 9.8e-8
Data Source: BioPlex
UBAC2
Novelty: 0.13384376
p_int: 0.960323525
p_ni: 0.039676406
p_wrong: 6.9e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
CDK15
Family: Kinase
Novelty: 0.3870338
p_int: 0.957657989
p_ni: 0.042342011
Data Source: BioPlex
SLCO6A1
Family: Transporter
Novelty: 0.07836028
p_int: 0.940958679
p_ni: 0.059041321
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 3 | 8 | 13 | 83.1 | |||||
BMI-adjusted hip circumference | 2 | 13 | 18 | 82.4 | |||||
type 2 diabetes mellitus | 3 | 1 | 2 | 1.1 | 60.7 | ||||
asparaginase-induced acute pancreatitis | 1 | 1 | 0 | 6.6 | 46.9 | ||||
BMI-adjusted waist-hip ratio | 3 | 2 | 5 | 41.1 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 13 | 83.1 | |||||
BMI-adjusted hip circumference | 18 | 82.4 | |||||
type 2 diabetes mellitus | 2 | 1.1 | 60.7 | ||||
asparaginase-induced acute pancreatitis | 0 | 6.6 | 46.9 | ||||
BMI-adjusted waist-hip ratio | 5 | 41.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | carboxypeptidase A4 | VGNC:4318 | 463727 | |||||
Macaque | carboxypeptidase A4 | 702856 | ||||||
Mouse | MGI:1919041 | 71791 | ||||||
Rat | RGD:1563619 | 502736 | ||||||
Dog | carboxypeptidase A4 | VGNC:39545 | 482258 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | carboxypeptidase A4 | |||||
Macaque | carboxypeptidase A4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | carboxypeptidase A4 | |||||
Publication Statistics
PubMed Score 97.08
PubMed score by year
PubTator Score 18.46
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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