Tchem CPA3 Mast cell carboxypeptidase A

Protein Summary

Description

This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P15088
• Q96E94
• MC-CPA

Gene Name

• CPA3

Ensembl ID

• ENST00000296046
• ENSP00000296046
• ENSG00000163751

Symbol

• MC-CPA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
PubMedID	0.76
virus perturbation	0.64
cell type or tissue	0.61
molecular function	0.56

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / Mast Cell Carboxypeptidase A

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Mast Cell Carboxypeptidase A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.32   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.32   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0