Protein Summary
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity). The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
- ENST00000264613
- ENSP00000264613
- ENSG00000047457
- CP-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.96 | ||
cell type or tissue | 0.95 | ||
biological term | 0.88 | ||
cellular component | 0.87 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 781.55 (req: < 5)
Gene RIFs: 118 (req: <= 3)
Antibodies: 344 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 781.55 (req: >= 5)
Gene RIFs: 118 (req: > 3)
Antibodies: 344 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (257)
DDX31
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999999838
p_ni: 1.49e-7
p_wrong: 1.3e-8
Score: 0.158
Data Source: BioPlex,STRINGDB
GDPD1
Family: Enzyme
Novelty: 0.28722153
p_int: 0.999999243
p_ni: 5.41e-7
p_wrong: 2.16e-7
Score: 0.247
Data Source: BioPlex,STRINGDB
SNX27
Novelty: 0.02419724
p_int: 0.999995688
p_ni: 0.000004301
p_wrong: 1.1e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (19)
Reactome (14)
KEGG (2)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective CP causes aceruloplasminemia (ACERULOP) | ||||
Reactome | Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | ||||
Reactome | Disease | ||||
Reactome | Disorders of transmembrane transporters | ||||
Reactome | Iron uptake and transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective CP causes aceruloplasminemia (ACERULOP) | ||||
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) | ||||
Disease | ||||
Disorders of transmembrane transporters | ||||
Iron uptake and transport | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (4)
Components (6)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 1 | 1 | 53.3 | |||||
serum ceruloplasmin measurement | 1 | 1 | 0 | 1.5 | 49.5 | ||||
mean reticulocyte volume | 1 | 1 | 1 | 13.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 53.3 | |||||
serum ceruloplasmin measurement | 0 | 1.5 | 49.5 | ||||
mean reticulocyte volume | 1 | 13.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ceruloplasmin | VGNC:11376 | 460768 | |||||
Macaque | ceruloplasmin | 712210 | ||||||
Mouse | MGI:88476 | 12870 | ||||||
Rat | RGD:2387 | 24268 | ||||||
Dog | ceruloplasmin | VGNC:39542 | 442963 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ceruloplasmin | |||||
Macaque | ceruloplasmin | |||||
Mouse | ||||||
Rat | ||||||
Dog | ceruloplasmin | |||||
Publication Statistics
PubMed Score 781.55
PubMed score by year
PubTator Score 3106.79
PubTator score by year
Related Publications
Text Mined References (173)
GeneRif Annotations (118)
Items per page:
0 of 0
PMID | Year | Title |
|---|