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Tbio
CP
Ceruloplasmin

Protein Summary
Description
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity). The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264613
  • ENSP00000264613
  • ENSG00000047457

Symbol
  • CP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
cell type or tissue
0.95
biological term
0.88
cellular component
0.87
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 781.55   (req: < 5)
Gene RIFs: 118   (req: <= 3)
Antibodies: 344   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 781.55   (req: >= 5)
Gene RIFs: 118   (req: > 3)
Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (257)
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999999838
p_ni:  1.49e-7
p_wrong:  1.3e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
p_int:  0.999999243
p_ni:  5.41e-7
p_wrong:  2.16e-7
Score:  0.247
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999995688
p_ni:  0.000004301
p_wrong:  1.1e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
SLC40A1
Tchem
Family:  Transporter
Novelty:  0.00222468
Score:  0.986
Data Source:  Reactome,STRINGDB
SERPINA1
Tbio
Novelty:  0.00014098
Score:  0.981
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.98
Data Source:  STRINGDB
TF
Tbio
Novelty:  0.00231826
Score:  0.967
Data Source:  STRINGDB
AHSG
Tbio
Novelty:  0.00112502
Score:  0.964
Data Source:  STRINGDB
C3
Tclin
Novelty:  0.00019115
Score:  0.963
Data Source:  STRINGDB
AFP
Tbio
Novelty:  0.00004755
Score:  0.957
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Defective CP causes aceruloplasminemia (ACERULOP) (R-HSA-5619060)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective CP causes aceruloplasminemia (ACERULOP)
Reactome
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Defective CP causes aceruloplasminemia (ACERULOP)
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)
Disease
Disorders of transmembrane transporters
Iron uptake and transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
53.3
serum ceruloplasmin measurement
1
1
0
1.5
49.5
mean reticulocyte volume
1
1
1
13.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
53.3
serum ceruloplasmin measurement
0
1.5
49.5
mean reticulocyte volume
1
13.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ceruloplasmin
VGNC:11376
460768
Macaque
ceruloplasmin
712210
Mouse
MGI:88476
12870
Rat
RGD:2387
24268
Dog
ceruloplasmin
VGNC:39542
442963
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ceruloplasmin
Macaque
ceruloplasmin
Mouse
Rat
Dog
ceruloplasmin
Publication Statistics
PubMed Score 781.55
PubMed score by year
PubTator Score 3106.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title