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Tbio
COX7A2L
Cytochrome c oxidase subunit 7A-related protein, mitochondrial

Protein Summary
Description
Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity). Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulator ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234301
  • ENSP00000234301
  • ENSG00000115944
  • ENST00000378669
  • ENSP00000367938

Symbol
  • COX7AR
  • COX7RP
  • EB1
  • SIG81
  • COX7AR
  • COX7RP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.98
co-expressed gene
0.96
histone modification site profile
0.75
transcription factor binding site profile
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.27   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.27   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
UQCRH
Tbio
Novelty:  0.04494433
p_int:  0.999986582
p_ni:  0.000013367
p_wrong:  5.1e-8
Score:  0.974
Data Source:  BioPlex,STRINGDB
UQCRQ
Tbio
Novelty:  0.04392627
p_int:  0.999974431
p_ni:  0.000025569
Score:  0.982
Data Source:  BioPlex,STRINGDB
UQCRB
Tbio
Novelty:  0.02933046
p_int:  0.999955686
p_ni:  0.000044314
p_wrong:  1e-9
Score:  0.917
Data Source:  BioPlex,STRINGDB
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
p_int:  0.999874921
p_ni:  0.000097885
p_wrong:  0.000027194
Data Source:  BioPlex
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.999819696
p_ni:  0.000180263
p_wrong:  4.2e-8
Score:  0.958
Data Source:  BioPlex,STRINGDB
COX5A
Tbio
Family:  Enzyme
Novelty:  0.02110193
p_int:  0.99926068
p_ni:  0.0007388
p_wrong:  5.21e-7
Score:  0.986
Data Source:  BioPlex,STRINGDB
COX6A1
Tbio
Family:  Enzyme
Novelty:  0.05543187
p_int:  0.998599826
p_ni:  0.001399731
p_wrong:  4.43e-7
Score:  0.977
Data Source:  BioPlex,STRINGDB
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
p_int:  0.99418228
p_ni:  0.001810534
p_wrong:  0.004007186
Data Source:  BioPlex
COX6C
Tbio
Family:  Enzyme
Novelty:  0.04365165
Score:  0.989
Data Source:  STRINGDB
COX7C
Tbio
Family:  Enzyme
Novelty:  0.05516787
Score:  0.979
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
1
6
80.5
1
1
0
2.3
64
BMI-adjusted hip circumference
1
3
3
54.2
IGF-1 measurement
1
1
1
44.2
insomnia measurement
1
1
0
1.1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
80.5
0
2.3
64
BMI-adjusted hip circumference
3
54.2
IGF-1 measurement
1
44.2
insomnia measurement
0
1.1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 7A2 like
VGNC:228
459181
Macaque
cytochrome c oxidase subunit 7A-related protein, mitochondrial
106992283
Mouse
MGI:106015
20463
Rat
RGD:1306111
298762
Dog
cytochrome c oxidase subunit 7A2 like
VGNC:39541
475739
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 7A2 like
Macaque
cytochrome c oxidase subunit 7A-related protein, mitochondrial
Mouse
Rat
Dog
cytochrome c oxidase subunit 7A2 like
Publication Statistics
PubMed Score 17.27
PubMed score by year
PubTator Score 7.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title