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Tbio
COX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

Protein Summary
Description
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230459
  • ENSP00000230459
  • ENSG00000112695

Symbol
  • COX7AL
  • VIIAL
  • COX7AL
  • COX7AL1
  • COXVIIAL
  • COXVIIa-L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
histone modification site profile
0.91
cellular component
0.74
transcription factor binding site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.12   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.12   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (160)
COX6B1
Tbio
Family:  Enzyme
Novelty:  0.02531055
p_int:  0.999998286
p_ni:  0.00000168
p_wrong:  3.4e-8
Score:  0.904
Data Source:  BioPlex,STRINGDB
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.999872427
p_ni:  0.000117006
p_wrong:  0.000010567
Score:  0.871
Data Source:  BioPlex,STRINGDB
COX6A1
Tbio
Family:  Enzyme
Novelty:  0.05543187
p_int:  0.999062967
p_ni:  0.000439417
p_wrong:  0.000497616
Score:  0.946
Data Source:  BioPlex,STRINGDB
NDUFAF7
Tbio
Family:  Enzyme
Novelty:  0.24691414
p_int:  0.977140842
p_ni:  0.022859071
p_wrong:  8.7e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
TOP3A
Tbio
Family:  Enzyme
Novelty:  0.0055546
p_int:  0.96830056
p_ni:  0.03169944
Score:  0.19
Data Source:  BioPlex,STRINGDB
DNLZ
Tdark
Novelty:  0.10113346
p_int:  0.950260411
p_ni:  0.049729241
p_wrong:  0.000010348
Score:  0.189
Data Source:  BioPlex,STRINGDB
CNDP1
Tbio
Family:  Enzyme
Novelty:  0.0102642
p_int:  0.804102899
p_ni:  0.195626906
p_wrong:  0.000270194
Score:  0.232
Data Source:  BioPlex,STRINGDB
MT-CO2
Tchem
Family:  Enzyme
Novelty:  0.00073921
Score:  0.998
Data Source:  STRINGDB
COX7C
Tbio
Family:  Enzyme
Novelty:  0.05516787
Score:  0.995
Data Source:  STRINGDB
COX6C
Tbio
Family:  Enzyme
Novelty:  0.04365165
Score:  0.986
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-alcoholic fatty liver disease (NAFLD)
KEGG
Alzheimer disease
KEGG
Huntington disease
KEGG
Thermogenesis
KEGG
Cardiac muscle contraction
Name
Explore in Pharos
Explore in Source
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer disease
Huntington disease
Thermogenesis
Cardiac muscle contraction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
2
2
2
64.5
bone density
1
1
1
60.7
cortical thickness
1
1
0
5.6
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
2
64.5
bone density
1
60.7
cortical thickness
0
5.6
0.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1316715
12866
Rat
RGD:68365
29507
Horse
cytochrome c oxidase subunit 7A2
VGNC:51019
100630209
Cow
cytochrome c oxidase subunit 7A2
VGNC:53788
327688
Pig
COX7A2 protein
100038000
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
cytochrome c oxidase subunit 7A2
Cow
cytochrome c oxidase subunit 7A2
Pig
COX7A2 protein
Publication Statistics
PubMed Score 25.12
PubMed score by year
PubTator Score 7.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title