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Tbio
COX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

Protein Summary
Description
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292907
  • ENSP00000292907
  • ENSG00000161281

Symbol
  • COX7AH
  • COX7A
  • COX7AH
  • COX7AM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
PubMedID
0.79
cellular component
0.65
transcription factor perturbation
0.61
molecular function
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.03   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.03   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
COX6C
Tbio
Family:  Enzyme
Novelty:  0.04365165
Score:  0.941
Data Source:  STRINGDB
COX6A2
Tbio
Family:  Enzyme
Novelty:  0.05368739
Score:  0.939
Data Source:  STRINGDB
COX6B1
Tbio
Family:  Enzyme
Novelty:  0.02531055
Score:  0.937
Data Source:  STRINGDB
COX5B
Tbio
Family:  Enzyme
Novelty:  0.01729026
Score:  0.934
Data Source:  STRINGDB
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
Score:  0.924
Data Source:  STRINGDB
COX7C
Tbio
Family:  Enzyme
Novelty:  0.05516787
Score:  0.922
Data Source:  STRINGDB
COX5A
Tbio
Family:  Enzyme
Novelty:  0.02110193
Score:  0.919
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.915
Data Source:  STRINGDB
COX6A1
Tbio
Family:  Enzyme
Novelty:  0.05543187
Score:  0.914
Data Source:  STRINGDB
COX7B
Tbio
Family:  Enzyme
Novelty:  0.09076141
Score:  0.911
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-alcoholic fatty liver disease (NAFLD)
KEGG
Alzheimer disease
KEGG
Huntington disease
KEGG
Thermogenesis
KEGG
Cardiac muscle contraction
Name
Explore in Pharos
Explore in Source
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer disease
Huntington disease
Thermogenesis
Cardiac muscle contraction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
3.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 7A1
VGNC:7609
100609529
Macaque
cytochrome c oxidase subunit 7AH
692060
Mouse
MGI:1316714
12865
Dog
cytochrome c oxidase subunit 7A1
VGNC:53694
612614
Horse
cytochrome c oxidase subunit 7A1
VGNC:51018
106782100
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 7A1
Macaque
cytochrome c oxidase subunit 7AH
Mouse
Dog
cytochrome c oxidase subunit 7A1
Horse
cytochrome c oxidase subunit 7A1
Publication Statistics
PubMed Score 34.03
PubMed score by year
PubTator Score 20.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title