COX6C
Cytochrome c oxidase subunit 6C
Protein Summary
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]
- ENST00000297564
- ENSP00000297564
- ENSG00000164919
- ENST00000517682
- ENSP00000429714
- ENST00000518171
- ENSP00000429755
- ENST00000520271
- ENSP00000428150
- ENST00000520468
- ENSP00000428895
- ENST00000520517
- ENSP00000429991
- ENST00000522934
- ENSP00000428702
- ENST00000522940
- ENSP00000428965
- ENST00000523016
- ENSP00000429707
- ENST00000524245
- ENSP00000429410
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.81 | ||
transcription factor perturbation | 0.8 | ||
disease perturbation | 0.79 | ||
PubMedID | 0.76 | ||
interacting protein | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.8 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 194 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.8 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 194 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0