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Tbio
COX6C
Cytochrome c oxidase subunit 6C

Protein Summary
Description
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297564
  • ENSP00000297564
  • ENSG00000164919
  • ENST00000517682
  • ENSP00000429714
  • ENST00000518171
  • ENSP00000429755
  • ENST00000520271
  • ENSP00000428150
  • ENST00000520468
  • ENSP00000428895
  • ENST00000520517
  • ENSP00000429991
  • ENST00000522934
  • ENSP00000428702
  • ENST00000522940
  • ENSP00000428965
  • ENST00000523016
  • ENSP00000429707
  • ENST00000524245
  • ENSP00000429410
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
transcription factor perturbation
0.8
disease perturbation
0.79
PubMedID
0.76
interacting protein
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.42   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.42   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
COX6A1
Tbio
Family:  Enzyme
Novelty:  0.05543187
p_int:  0.999575623
p_ni:  0.000424377
Score:  0.995
Data Source:  BioPlex,STRINGDB
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.999555536
p_ni:  0.000444464
Score:  0.999
Data Source:  BioPlex,STRINGDB
COX6B1
Tbio
Family:  Enzyme
Novelty:  0.02531055
Score:  0.999
Data Source:  STRINGDB
MT-CO2
Tchem
Family:  Enzyme
Novelty:  0.00073921
Score:  0.999
Data Source:  STRINGDB
COX5A
Tbio
Family:  Enzyme
Novelty:  0.02110193
Score:  0.999
Data Source:  STRINGDB
COX7C
Tbio
Family:  Enzyme
Novelty:  0.05516787
Score:  0.999
Data Source:  STRINGDB
COX5B
Tbio
Family:  Enzyme
Novelty:  0.01729026
Score:  0.999
Data Source:  STRINGDB
UQCRQ
Tbio
Novelty:  0.04392627
Score:  0.995
Data Source:  STRINGDB
COX6A2
Tbio
Family:  Enzyme
Novelty:  0.05368739
Score:  0.995
Data Source:  STRINGDB
COX7B
Tbio
Family:  Enzyme
Novelty:  0.09076141
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
64.4
heel bone mineral density
2
2
2
63.6
mean corpuscular hemoglobin concentration
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
64.4
heel bone mineral density
2
63.6
mean corpuscular hemoglobin concentration
1
56.4
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 6C
VGNC:903
741071
Macaque
cytochrome c oxidase subunit 6C
100428417
Mouse
MGI:104614
12864
Rat
RGD:620616
54322
Rat
RGD:735056
286962
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 6C
Macaque
cytochrome c oxidase subunit 6C
Mouse
Rat
Rat
Publication Statistics
PubMed Score 21.42
PubMed score by year
PubTator Score 8.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title