COX6C
Cytochrome c oxidase subunit 6C
Protein Summary
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]
- ENST00000297564
- ENSP00000297564
- ENSG00000164919
- ENST00000517682
- ENSP00000429714
- ENST00000518171
- ENSP00000429755
- ENST00000520271
- ENSP00000428150
- ENST00000520468
- ENSP00000428895
- ENST00000520517
- ENSP00000429991
- ENST00000522934
- ENSP00000428702
- ENST00000522940
- ENSP00000428965
- ENST00000523016
- ENSP00000429707
- ENST00000524245
- ENSP00000429410
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.81 | ||
transcription factor perturbation | 0.8 | ||
disease perturbation | 0.79 | ||
PubMedID | 0.76 | ||
interacting protein | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.42 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 194 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.42 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 194 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (141)
COX6A1
Family: Enzyme
Novelty: 0.05543187
p_int: 0.999575623
p_ni: 0.000424377
Score: 0.995
Data Source: BioPlex,STRINGDB
COX4I1
Family: Enzyme
Novelty: 0.00208873
p_int: 0.999555536
p_ni: 0.000444464
Score: 0.999
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (20)
Reactome (9)
KEGG (8)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Metabolism | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | Respiratory electron transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Metabolism | ||||
RNA Polymerase II Transcription | ||||
Respiratory electron transport | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (1)
Components (3)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.1 | 64.4 | |||||
heel bone mineral density | 2 | 2 | 2 | 63.6 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 56.4 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 64.4 | |||||
heel bone mineral density | 2 | 63.6 | |||||
mean corpuscular hemoglobin concentration | 1 | 56.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytochrome c oxidase subunit 6C | VGNC:903 | 741071 | |||||
Macaque | cytochrome c oxidase subunit 6C | 100428417 | ||||||
Mouse | MGI:104614 | 12864 | ||||||
Rat | RGD:620616 | 54322 | ||||||
Rat | RGD:735056 | 286962 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytochrome c oxidase subunit 6C | |||||
Macaque | cytochrome c oxidase subunit 6C | |||||
Mouse | ||||||
Rat | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 21.42
PubMed score by year
PubTator Score 8.28
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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