Tbio COX6C Cytochrome c oxidase subunit 6C

Protein Summary

Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• P09669
• B2R4D7

Gene Name

• COX6C

Ensembl ID

• ENST00000297564
• ENSP00000297564
• ENSG00000164919
• ENST00000517682
• ENSP00000429714
• ENST00000518171
• ENSP00000429755
• ENST00000520271
• ENSP00000428150
• ENST00000520468
• ENSP00000428895
• ENST00000520517
• ENSP00000429991
• ENST00000522934
• ENSP00000428702
• ENST00000522940
• ENSP00000428965
• ENST00000523016
• ENSP00000429707
• ENST00000524245
• ENSP00000429410

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.81
transcription factor perturbation	0.8
disease perturbation	0.79
PubMedID	0.76
interacting protein	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.8   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.8   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0