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Tbio
COX6B1
Cytochrome c oxidase subunit 6B1

Protein Summary
Description
Connects the two COX monomers into the physiological dimeric form. Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246554
  • ENSP00000246554
  • ENSG00000126267
  • ENST00000392201
  • ENSP00000376037
  • ENST00000592141
  • ENSP00000466818
  • ENST00000649813
  • ENSP00000497926

Symbol
  • COX6B
  • COXG
  • COX6B
  • COXVIb1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
disease perturbation
0.79
co-expressed gene
0.76
gene perturbation
0.74
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.66   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.66   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (175)
COX6A1
Tbio
Family:  Enzyme
Novelty:  0.05543187
p_int:  0.999999595
p_ni:  4.04e-7
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
COX7A2
Tbio
Family:  Enzyme
Novelty:  0.04287864
p_int:  0.999998286
p_ni:  0.00000168
p_wrong:  3.4e-8
Score:  0.904
Data Source:  BioPlex,STRINGDB
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.999995256
p_ni:  0.000004744
Score:  0.996
Data Source:  BioPlex,STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.999913139
p_ni:  0.000041087
p_wrong:  0.000045775
Score:  0.154
Data Source:  BioPlex,STRINGDB
CASD1
Tbio
Novelty:  0.08152119
p_int:  0.998927756
p_ni:  0.001072237
p_wrong:  8e-9
Data Source:  BioPlex
UQCRQ
Tbio
Novelty:  0.04392627
p_int:  0.998700791
p_ni:  0.001298726
p_wrong:  4.82e-7
Score:  0.989
Data Source:  BioPlex,STRINGDB
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.994189187
p_ni:  0.005810809
p_wrong:  4e-9
Score:  0.676
Data Source:  BioPlex,STRINGDB
UQCRB
Tbio
Novelty:  0.02933046
p_int:  0.96209047
p_ni:  0.037909528
p_wrong:  2e-9
Score:  0.963
Data Source:  BioPlex,STRINGDB
SUOX
Tbio
Family:  Enzyme
Novelty:  0.00971136
p_int:  0.895002791
p_ni:  0.012089806
p_wrong:  0.092907403
Score:  0.228
Data Source:  BioPlex,STRINGDB
CAV1
Tbio
Novelty:  0.00035244
p_int:  0.89248385
p_ni:  0.107514612
p_wrong:  0.000001538
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
64.9
self reported educational attainment
1
1
1
46.1
mathematical ability
1
1
1
38.8
eosinophil percentage of leukocytes
1
1
1
37.6
platelet count
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
64.9
self reported educational attainment
1
46.1
mathematical ability
1
38.8
eosinophil percentage of leukocytes
1
37.6
platelet count
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 6B1
VGNC:7610
745426
Macaque
cytochrome c oxidase subunit 6B
692062
Mouse
MGI:107460
110323
Rat
Dog
cytochrome c oxidase subunit 6B1
612644
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 6B1
Macaque
cytochrome c oxidase subunit 6B
Mouse
Rat
Dog
cytochrome c oxidase subunit 6B1
Publication Statistics
PubMed Score 38.66
PubMed score by year
PubTator Score 9.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title