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Tbio
COX6A2
Cytochrome c oxidase subunit 6A2, mitochondrial

Protein Summary
Description
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287490
  • ENSP00000287490
  • ENSG00000156885

Symbol
  • COX6A
  • COX6AH
  • COX6AH
  • COXVIAH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.74
small molecule perturbation
0.69
cellular component
0.68
molecular function
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.45   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.45   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (160)
COX5A
Tbio
Family:  Enzyme
Novelty:  0.02110193
Score:  0.997
Data Source:  STRINGDB
COX5B
Tbio
Family:  Enzyme
Novelty:  0.01729026
Score:  0.996
Data Source:  STRINGDB
COX6C
Tbio
Family:  Enzyme
Novelty:  0.04365165
Score:  0.995
Data Source:  STRINGDB
UQCRQ
Tbio
Novelty:  0.04392627
Score:  0.993
Data Source:  STRINGDB
COX6B1
Tbio
Family:  Enzyme
Novelty:  0.02531055
Score:  0.987
Data Source:  STRINGDB
COX4I2
Tbio
Family:  Enzyme
Novelty:  0.00965049
Score:  0.985
Data Source:  STRINGDB
COX7C
Tbio
Family:  Enzyme
Novelty:  0.05516787
Score:  0.985
Data Source:  STRINGDB
UQCR10
Tbio
Novelty:  0.04536078
Score:  0.983
Data Source:  STRINGDB
COX6B2
Tbio
Family:  Enzyme
Novelty:  0.1103017
Score:  0.983
Data Source:  STRINGDB
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
Score:  0.982
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-alcoholic fatty liver disease (NAFLD)
KEGG
Alzheimer disease
KEGG
Huntington disease
KEGG
Thermogenesis
KEGG
Cardiac muscle contraction
Name
Explore in Pharos
Explore in Source
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer disease
Huntington disease
Thermogenesis
Cardiac muscle contraction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.2
93.8
Glycosuria
5
3
0
4.1
90.3
blood protein measurement
3
4
4
85.2
1
1
0
1.3
71.8
body mass index
1
1
1
60.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
93.8
Glycosuria
0
4.1
90.3
blood protein measurement
4
85.2
0
1.3
71.8
body mass index
1
60.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 6A2
VGNC:8973
742678
Mouse
MGI:104649
12862
Rat
RGD:2385
25278
Dog
cytochrome c oxidase subunit VIa polypeptide 2
479780
Horse
cytochrome c oxidase subunit 6A2
VGNC:16806
100063197
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 6A2
Mouse
Rat
Dog
cytochrome c oxidase subunit VIa polypeptide 2
Horse
cytochrome c oxidase subunit 6A2
Publication Statistics
PubMed Score 21.45
PubMed score by year
PubTator Score 4.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title