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Tbio
COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

Protein Summary
Description
This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322347
  • ENSP00000317780
  • ENSG00000178741
  • ENST00000564811
  • ENSP00000456386

Symbol
  • VA
  • COX
  • COX-VA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.94
disease perturbation
0.93
transcription factor binding site profile
0.9
co-expressed gene
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.72   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.72   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (227)
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.99952621
p_ni:  0.000473791
Score:  0.999
Data Source:  BioPlex,STRINGDB
COX7A2L
Tbio
Family:  Enzyme
Novelty:  0.06920916
p_int:  0.99926068
p_ni:  0.0007388
p_wrong:  5.21e-7
Score:  0.986
Data Source:  BioPlex,STRINGDB
SLC30A9
Tbio
Family:  Transporter
Novelty:  0.07156604
p_int:  0.995319715
p_ni:  0.004680285
Score:  0.309
Data Source:  BioPlex,STRINGDB
MT-CO1
Tchem
Family:  Enzyme
Novelty:  0.00008262
p_int:  0.760365726
p_ni:  0.239634274
Score:  0.996
Data Source:  BioPlex,STRINGDB
COX7C
Tbio
Family:  Enzyme
Novelty:  0.05516787
Score:  0.999
Data Source:  STRINGDB
COX6B1
Tbio
Family:  Enzyme
Novelty:  0.02531055
Score:  0.999
Data Source:  STRINGDB
MT-CO2
Tchem
Family:  Enzyme
Novelty:  0.00073921
Score:  0.999
Data Source:  STRINGDB
COX6C
Tbio
Family:  Enzyme
Novelty:  0.04365165
Score:  0.999
Data Source:  STRINGDB
COX5B
Tbio
Family:  Enzyme
Novelty:  0.01729026
Score:  0.999
Data Source:  STRINGDB
COX6A1
Tbio
Family:  Enzyme
Novelty:  0.05543187
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
2
2
2
81.6
cups of coffee per day measurement
1
2
2
80.6
red blood cell density measurement
1
1
1
80
monocyte count
2
2
2
78.9
monocyte percentage of leukocytes
1
1
1
78.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
2
81.6
cups of coffee per day measurement
2
80.6
red blood cell density measurement
1
80
monocyte count
2
78.9
monocyte percentage of leukocytes
1
78.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 5A
VGNC:3562
453750
Macaque
cytochrome c oxidase subunit 5A
692061
Mouse
MGI:88474
12858
Rat
RGD:620607
252934
Dog
cytochrome c oxidase subunit Va
478370
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 5A
Macaque
cytochrome c oxidase subunit 5A
Mouse
Rat
Dog
cytochrome c oxidase subunit Va
Publication Statistics
PubMed Score 44.72
PubMed score by year
PubTator Score 14.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title