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Tbio
COX4I1
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Protein Summary
Description
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253452
  • ENSP00000253452
  • ENSG00000131143
  • ENST00000561569
  • ENSP00000457015
  • ENST00000562336
  • ENSP00000457513

Symbol
  • COX4
  • COX4
  • COXIV
  • COX4-1
  • COXIV-1
  • COX IV-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.99
transcription factor perturbation
0.96
interacting protein
0.87
histone modification site profile
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.78   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 789   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.78   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 789   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (276)
PIGA
Tbio
Family:  Enzyme
Novelty:  0.00172769
p_int:  0.999995483
p_ni:  0.000004517
Data Source:  BioPlex
COX6B1
Tbio
Family:  Enzyme
Novelty:  0.02531055
p_int:  0.999995256
p_ni:  0.000004744
Score:  0.996
Data Source:  BioPlex,STRINGDB
PIGH
Tbio
Family:  Enzyme
Novelty:  0.0584561
p_int:  0.999939388
p_ni:  0.000060612
Data Source:  BioPlex
COX7A2
Tbio
Family:  Enzyme
Novelty:  0.04287864
p_int:  0.999872427
p_ni:  0.000117006
p_wrong:  0.000010567
Score:  0.871
Data Source:  BioPlex,STRINGDB
CRAT
Tbio
Family:  Enzyme
Novelty:  0.01242609
p_int:  0.999868245
p_ni:  0.000104065
p_wrong:  0.00002769
Data Source:  BioPlex
COX7A2L
Tbio
Family:  Enzyme
Novelty:  0.06920916
p_int:  0.999819696
p_ni:  0.000180263
p_wrong:  4.2e-8
Score:  0.958
Data Source:  BioPlex,STRINGDB
SLC30A9
Tbio
Family:  Transporter
Novelty:  0.07156604
p_int:  0.999609431
p_ni:  0.000390569
Data Source:  BioPlex
COX6C
Tbio
Family:  Enzyme
Novelty:  0.04365165
p_int:  0.999555536
p_ni:  0.000444464
Score:  0.999
Data Source:  BioPlex,STRINGDB
COX5A
Tbio
Family:  Enzyme
Novelty:  0.02110193
p_int:  0.99952621
p_ni:  0.000473791
Score:  0.999
Data Source:  BioPlex,STRINGDB
MT-CO1
Tchem
Family:  Enzyme
Novelty:  0.00008262
p_int:  0.998243788
p_ni:  0.001756212
Score:  0.992
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
8
9
99.5
monocyte count
3
6
6
99.4
granulocyte percentage of myeloid white cells
1
4
4
98.4
neutrophil count
3
4
4
96.1
neutrophil percentage of leukocytes
2
2
2
94.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
9
99.5
monocyte count
6
99.4
granulocyte percentage of myeloid white cells
4
98.4
neutrophil count
4
96.1
neutrophil percentage of leukocytes
2
94.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 4I1
VGNC:9043
454391
Macaque
cytochrome c oxidase subunit IV isoform 1
693811
Mouse
MGI:88473
12857
Rat
RGD:68374
29445
Dog
cytochrome c oxidase subunit 4I1
VGNC:39539
479623
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase subunit 4I1
Macaque
cytochrome c oxidase subunit IV isoform 1
Mouse
Rat
Dog
cytochrome c oxidase subunit 4I1
Publication Statistics
PubMed Score 382.78
PubMed score by year
PubTator Score 121.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title