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Tbio
COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

Protein Summary
Description
Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:23125284). Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme (PubMed:24403053). This gene encodes a protein that plays a role in the assembly of cytochrome C oxidase, an important component of the respiratory pathway. It contains two transmembrane helices and localizes to the mitochondrial membrane. Mutations in this gene can cause mitochondrial complex IV deficiency, which results in ataxia and muscle hypotonia. There are multiple pseudogenes for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366528
  • ENSP00000355486
  • ENSG00000203667
  • ENST00000411948
  • ENSP00000406327

Symbol
  • FAM36A
  • FAM36A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
small molecule perturbation
0.73
histone modification site profile
0.71
cell type or tissue
0.63
PubMedID
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.18   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.18   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
UQCC1
Tbio
Family:  Enzyme
Novelty:  0.03937066
p_int:  0.999244727
p_ni:  0.000755272
Score:  0.702
Data Source:  BioPlex,STRINGDB
UQCC2
Tbio
Family:  Enzyme
Novelty:  0.02059646
p_int:  0.993065203
p_ni:  0.006934633
p_wrong:  1.65e-7
Score:  0.813
Data Source:  BioPlex,STRINGDB
CCSMST1
Tdark
Novelty:  0.60610244
p_int:  0.992161286
p_ni:  0.000001088
p_wrong:  0.007837626
Score:  0.685
Data Source:  BioPlex,STRINGDB
ECM1
Tbio
Novelty:  0.00518679
p_int:  0.807247927
p_ni:  0.192752038
p_wrong:  3.5e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.944
Data Source:  STRINGDB
COX18
Tbio
Novelty:  0.06288021
Score:  0.882
Data Source:  STRINGDB
COA5
Tdark
Family:  Enzyme
Novelty:  0.1358881
Score:  0.799
Data Source:  STRINGDB
SCO1
Tbio
Novelty:  0.01012315
Score:  0.769
Data Source:  STRINGDB
MT-CO2
Tchem
Family:  Enzyme
Novelty:  0.00073921
Score:  0.761
Data Source:  STRINGDB
SURF1
Tbio
Novelty:  0.00717605
Score:  0.749
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
18.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
COX20, cytochrome c oxidase assembly factor
VGNC:12983
736354
Macaque
COX20 Cox2 chaperone homolog
704298
Mouse
MGI:1913609
66359
Rat
RGD:1309105
289278
Horse
COX20, cytochrome c oxidase assembly factor
VGNC:16800
100630213
Species
Name
OMA
EggNOG
Inparanoid
Chimp
COX20, cytochrome c oxidase assembly factor
Macaque
COX20 Cox2 chaperone homolog
Mouse
Rat
Horse
COX20, cytochrome c oxidase assembly factor
Publication Statistics
PubMed Score 27.18
PubMed score by year
PubTator Score 6.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title