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Tbio
COX15
Cytochrome c oxidase assembly protein COX15 homolog

Protein Summary
Description
May be involved in the biosynthesis of heme A. Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000016171
  • ENSP00000016171
  • ENSG00000014919
  • ENST00000370483
  • ENSP00000359514

Symbol
  • CEMCOX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
kinase perturbation
0.88
microRNA
0.81
tissue sample
0.76
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.86   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.86   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (156)
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.782615437
p_ni:  0.217384563
Data Source:  BioPlex
COX10
Tbio
Family:  Enzyme
Novelty:  0.0156235
Score:  0.995
Data Source:  STRINGDB
SURF1
Tbio
Novelty:  0.00717605
Score:  0.991
Data Source:  STRINGDB
CYC1
Tchem
Novelty:  0.01369865
Score:  0.97
Data Source:  STRINGDB
SCO1
Tbio
Novelty:  0.01012315
Score:  0.954
Data Source:  STRINGDB
MT-CO3
Tbio
Family:  Enzyme
Novelty:  0.00253369
Score:  0.952
Data Source:  STRINGDB
MT-CO1
Tchem
Family:  Enzyme
Novelty:  0.00008262
Score:  0.943
Data Source:  STRINGDB
MT-CO2
Tchem
Family:  Enzyme
Novelty:  0.00073921
Score:  0.927
Data Source:  STRINGDB
COX11
Tbio
Family:  Enzyme
Novelty:  0.02572582
Score:  0.924
Data Source:  STRINGDB
NDUFS8
Tclin
Family:  Enzyme
Novelty:  0.02408724
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Heme biosynthesis (R-HSA-189451)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Heme biosynthesis
Reactome
Metabolism
Reactome
Metabolism of porphyrins
Name
Explore in Pharos
Explore in Source
Heme biosynthesis
Metabolism
Metabolism of porphyrins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
2
2
85
bilirubin measurement
1
2
2
65.3
serum alanine aminotransferase measurement
1
1
1
32.6
aspartate aminotransferase measurement
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
85
bilirubin measurement
2
65.3
serum alanine aminotransferase measurement
1
32.6
aspartate aminotransferase measurement
1
6.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
COX15, cytochrome c oxidase assembly homolog
VGNC:13048
744451
Macaque
cytochrome c oxidase assembly protein COX15 homolog
708964
Mouse
MGI:1920112
226139
Rat
RGD:1312043
309391
Dog
COX15, cytochrome c oxidase assembly homolog
VGNC:39535
477792
Species
Name
OMA
EggNOG
Inparanoid
Chimp
COX15, cytochrome c oxidase assembly homolog
Macaque
cytochrome c oxidase assembly protein COX15 homolog
Mouse
Rat
Dog
COX15, cytochrome c oxidase assembly homolog
Publication Statistics
PubMed Score 45.86
PubMed score by year
PubTator Score 11.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title