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Tbio
COX14
Cytochrome c oxidase assembly protein COX14

Protein Summary
Description
Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1. This gene encodes a small single-pass transmembrane protein that localizes to mitochondria. This protein may play a role in coordinating the early steps of cytochrome c oxidase (COX; also known as complex IV) subunit assembly and, in particular, the synthesis and assembly of the COX I subunit of the holoenzyme. Mutations in this gene have been associated with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317943
  • ENSP00000326052
  • ENSG00000178449
  • ENST00000548985
  • ENSP00000447776
  • ENST00000550487
  • ENSP00000446524
  • ENST00000550654
  • ENSP00000450331

Symbol
  • C12orf62
  • PCAG1
  • C12orf62
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
kinase perturbation
0.84
histone modification site profile
0.71
transcription factor
0.6
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.7   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 11   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.7   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
COA3
Tbio
Family:  Enzyme
Novelty:  0.04949473
p_int:  0.949573752
p_ni:  0.000015349
p_wrong:  0.050410899
Score:  0.829
Data Source:  BioPlex,STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.94
Data Source:  STRINGDB
COX5B
Tbio
Family:  Enzyme
Novelty:  0.01729026
Score:  0.899
Data Source:  STRINGDB
UQCR10
Tbio
Novelty:  0.04536078
Score:  0.866
Data Source:  STRINGDB
MSS51
Tbio
Novelty:  0.06388791
Score:  0.836
Data Source:  STRINGDB
ATP5ME
Tbio
Family:  Enzyme
Novelty:  0.12559724
Score:  0.803
Data Source:  STRINGDB
COX15
Tbio
Family:  Enzyme
Novelty:  0.02252282
Score:  0.78
Data Source:  STRINGDB
MP68
Tbio
Novelty:  0.04752198
Score:  0.759
Data Source:  STRINGDB
COA6
Tbio
Family:  Enzyme
Novelty:  0.09500476
Score:  0.754
Data Source:  STRINGDB
TACO1
Tbio
Family:  Enzyme
Novelty:  0.10710318
Score:  0.751
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
2
2
86.9
myeloid white cell count
1
1
1
65.5
neutrophil count
1
1
1
61.6
2
1
0
6.2
59.9
comparative body size at age 10, self-reported
1
1
1
53.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
2
86.9
myeloid white cell count
1
65.5
neutrophil count
1
61.6
0
6.2
59.9
comparative body size at age 10, self-reported
1
53.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913629
66379
Rat
RGD:1598052
681219
Dog
COX14, cytochrome c oxidase assembly factor
VGNC:39534
100688544
Horse
COX14, cytochrome c oxidase assembly factor [Source:HGNC Symbol;Acc:HGNC:28216]
Cow
COX14, cytochrome c oxidase assembly factor
VGNC:27628
768048
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
COX14, cytochrome c oxidase assembly factor
Horse
COX14, cytochrome c oxidase assembly factor [Source:HGNC Symbol;Acc:HGNC:28216]
Cow
COX14, cytochrome c oxidase assembly factor
Publication Statistics
PubMed Score 11.70
PubMed score by year
PubTator Score 2.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title