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Tbio
COX10
Protoheme IX farnesyltransferase, mitochondrial

Protein Summary
Description
Converts protoheme IX and farnesyl diphosphate to heme O. Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261643
  • ENSP00000261643
  • ENSG00000006695
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor perturbation
0.8
transcription factor binding site profile
0.78
cellular component
0.76
molecular function
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.08   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.08   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (162)
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.999859232
p_ni:  1.26e-7
p_wrong:  0.000140642
Score:  0.202
Data Source:  BioPlex,STRINGDB
COX15
Tbio
Family:  Enzyme
Novelty:  0.02252282
Score:  0.995
Data Source:  STRINGDB
MT-CO1
Tchem
Family:  Enzyme
Novelty:  0.00008262
Score:  0.974
Data Source:  STRINGDB
MT-CO3
Tbio
Family:  Enzyme
Novelty:  0.00253369
Score:  0.967
Data Source:  STRINGDB
SURF1
Tbio
Novelty:  0.00717605
Score:  0.956
Data Source:  STRINGDB
MT-CO2
Tchem
Family:  Enzyme
Novelty:  0.00073921
Score:  0.952
Data Source:  STRINGDB
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
Score:  0.95
Data Source:  STRINGDB
HCCS
Tbio
Family:  Enzyme
Novelty:  0.0022585
Score:  0.95
Data Source:  STRINGDB
HMOX1
Tchem
Family:  Enzyme
Novelty:  0.00013981
Score:  0.906
Data Source:  STRINGDB
HMOX2
Tchem
Family:  Enzyme
Novelty:  0.00180703
Score:  0.905
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Heme biosynthesis (R-HSA-189451)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Heme biosynthesis
Reactome
Metabolism
Reactome
Metabolism of porphyrins
Name
Explore in Pharos
Explore in Source
Heme biosynthesis
Metabolism
Metabolism of porphyrins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
2
1
7
58.3
1
1
0
6.4
21.5
Myopia
1
1
0
7
13.7
age at onset
1
1
0
7
13.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
7
58.3
0
6.4
21.5
Myopia
0
7
13.7
age at onset
0
7
13.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor
VGNC:9248
465445
Macaque
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
718301
Mouse
MGI:1917633
70383
Rat
RGD:1594623
691853
Dog
COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor
VGNC:39533
489515
Species
Name
OMA
EggNOG
Inparanoid
Chimp
COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor
Macaque
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
Mouse
Rat
Dog
COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor
Publication Statistics
PubMed Score 66.08
PubMed score by year
PubTator Score 24.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title