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Tbio
CORO7
Coronin-7

Protein Summary
Description
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a n ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251166
  • ENSP00000251166
  • ENSG00000262246
  • ENST00000537233
  • ENSP00000440460
  • ENST00000574025
  • ENSP00000461702
  • ENST00000614702
  • ENSP00000482646
  • ENSG00000282725
  • ENST00000617235
  • ENSP00000483187
  • ENST00000631534
  • ENSP00000488867

Symbol
  • CRN7
  • POD1
  • 0610011B16Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor
0.79
transcription factor binding site profile
0.77
tissue
0.7
cell type or tissue
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.21   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.21   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
CNTF
Tbio
Novelty:  0.00091188
p_int:  0.999961649
p_ni:  0.00003835
Data Source:  BioPlex
THBS3
Tbio
Novelty:  0.01915634
p_int:  0.999783802
p_ni:  0.000216191
p_wrong:  7e-9
Data Source:  BioPlex
ASB6
Tdark
Novelty:  0.32074223
p_int:  0.997390921
p_ni:  0.002272149
p_wrong:  0.00033693
Data Source:  BioPlex
AZIN2
Tbio
Family:  Enzyme
Novelty:  0.00750311
p_int:  0.995885494
p_ni:  0.003568459
p_wrong:  0.000546046
Data Source:  BioPlex
KLHL20
Tbio
Novelty:  0.12205871
p_int:  0.995736382
p_ni:  0.003654875
p_wrong:  0.000608742
Score:  0.677
Data Source:  BioPlex,STRINGDB
TCF21
Tbio
Family:  TF
Novelty:  0.0005831
Score:  0.805
Data Source:  STRINGDB
KBTBD8
Tbio
Novelty:  0.42601278
Score:  0.713
Data Source:  STRINGDB
DNAJC19
Tbio
Family:  Enzyme
Novelty:  0.02938164
Score:  0.658
Data Source:  STRINGDB
TIMM44
Tbio
Family:  Enzyme
Novelty:  0.020862
Score:  0.653
Data Source:  STRINGDB
DNAJC15
Tbio
Novelty:  0.05605564
Score:  0.647
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (38)
Items per page:
1 – 5 of 38
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
10
17
27
95.7
BMI-adjusted waist-hip ratio
10
17
27
95.7
BMI-adjusted hip circumference
3
13
14
92.7
BMI-adjusted hip circumference
3
13
14
92.7
hip circumference
1
5
5
87.5
Items per page:
1 – 5 of 38
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
27
95.7
BMI-adjusted waist-hip ratio
27
95.7
BMI-adjusted hip circumference
14
92.7
BMI-adjusted hip circumference
14
92.7
hip circumference
5
87.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1926135
78885
Cow
coronin 7
527934
Opossum
coronin-7
100015171
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Cow
coronin 7
Opossum
coronin-7
Publication Statistics
PubMed Score 5.21
PubMed score by year
PubTator Score 687.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title