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Tbio
CORO2A
Coronin-2A

Protein Summary
Description
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343933
  • ENSP00000343746
  • ENSG00000106789
  • ENST00000375077
  • ENSP00000364218

Symbol
  • IR10
  • WDR2
  • IR10
  • WDR2
  • CLIPINB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
virus perturbation
0.96
histone modification site profile
0.82
transcription factor binding site profile
0.64
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.81   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.81   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
CORO2B
Tdark
Novelty:  0.30665394
p_int:  0.999999998
p_ni:  2e-9
Score:  0.324
Data Source:  BioPlex,STRINGDB
RGS3
Tbio
Novelty:  0.01749541
p_int:  0.999658679
p_ni:  0.000341317
p_wrong:  4e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
CSN2
Tbio
Family:  Enzyme
Novelty:  0.00050291
p_int:  0.998388223
p_ni:  0.001611658
p_wrong:  1.19e-7
Score:  0.379
Data Source:  BioPlex,STRINGDB
ERH
Tbio
Novelty:  0.00711649
p_int:  0.990504285
p_ni:  0.009494739
p_wrong:  9.76e-7
Data Source:  BioPlex
SLC5A8
Tchem
Family:  Transporter
Novelty:  0.00892277
p_int:  0.968876848
p_ni:  0.011389121
p_wrong:  0.019734031
Score:  0.165
Data Source:  BioPlex,STRINGDB
FERD3L
Tbio
Family:  TF
Novelty:  0.06797434
p_int:  0.906730442
p_ni:  0.06902017
p_wrong:  0.024249387
Score:  0.228
Data Source:  BioPlex,STRINGDB
AHI1
Tbio
Novelty:  0.01180688
p_int:  0.864881683
p_ni:  0.053724006
p_wrong:  0.081394311
Data Source:  BioPlex
BCLAF1
Tbio
Novelty:  0.01535146
p_int:  0.853141563
p_ni:  0.146858437
Score:  0.239
Data Source:  BioPlex,STRINGDB
COP1
Tbio
Family:  Enzyme
Novelty:  0.10908534
Score:  0.727
Data Source:  STRINGDB
WDR1
Tbio
Novelty:  0.01524342
Score:  0.724
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
50.6
mean corpuscular volume
1
1
1
50.5
1
1
0
1.1
44.2
high density lipoprotein cholesterol measurement
1
1
1
4.3
apolipoprotein A 1 measurement
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
50.6
mean corpuscular volume
1
50.5
0
1.1
44.2
high density lipoprotein cholesterol measurement
1
4.3
apolipoprotein A 1 measurement
1
0.5
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coronin 2A
VGNC:8809
464607
Macaque
coronin 2A
715369
Mouse
MGI:1345966
107684
Rat
RGD:1309719
313235
Dog
coronin 2A
VGNC:39529
481625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coronin 2A
Macaque
coronin 2A
Mouse
Rat
Dog
coronin 2A
Publication Statistics
PubMed Score 29.81
PubMed score by year
PubTator Score 23.18
PubTator score by year
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Related Publications
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PMID
Year
Title