Tbio CORO1A Coronin-1A

Protein Summary

Description

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• P31146
• B2RBL1
• Q2YD73

Gene Name

• CORO1A

Ensembl ID

• ENST00000219150
• ENSP00000219150
• ENSG00000102879
• ENST00000570045
• ENSP00000455552

Symbol

• CORO1
• p57
• IMD8
• TACO
• CLABP
• HCORO1
• CLIPINA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
biological process	0.96
gene perturbation	0.95
transcription factor perturbation	0.88
small molecule perturbation	0.87

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Coronin-1a

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Coronin-1a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.77   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 427   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.77   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 427   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (128)

Explore Interacting Targets

1 – 10 of 128

• See Interactions on String-DB

CORO6

Tdark

Novelty:  0.37416507

p_int:  1

Score:  0.667

Data Source:  BioPlex,STRINGDB

IFT57

Tbio

Novelty:  0.03373199

p_int:  1

Score:  0.538

Data Source:  BioPlex,STRINGDB

POC1A

Tbio

Novelty:  0.03897985

p_int:  0.999999921

p_ni:  7.9e-8

Score:  0.665

Data Source:  BioPlex,STRINGDB

POC1B

Tbio

Novelty:  0.09023863

p_int:  0.99999988

p_ni:  1.2e-7

Score:  0.813

Data Source:  BioPlex,STRINGDB

TJAP1

Tbio

Novelty:  0.008967

p_int:  0.999999707

p_ni:  1.89e-7

p_wrong:  1.04e-7

Score:  0.211

Data Source:  BioPlex,STRINGDB

RABGAP1

Tbio

Family:  Enzyme

Novelty:  0.14270101

p_int:  0.999999693

p_ni:  3.07e-7

Score:  0.161

Data Source:  BioPlex,STRINGDB

IFT80

Tbio

Novelty:  0.04862973

p_int:  0.999998933

p_ni:  0.000001062

p_wrong:  5e-9

Score:  0.825

Data Source:  BioPlex,STRINGDB

B7ZAP0

Tbio

Family:  Enzyme

Novelty:  0.2377644

p_int:  0.999956616

p_ni:  0.000043384

Score:  0.166

Data Source:  BioPlex,STRINGDB

MATN2

Tbio

Novelty:  0.08506252

p_int:  0.999946269

p_ni:  0.000053731

Data Source:  BioPlex

CORO1C

Tbio

Novelty:  0.02068813

p_int:  0.999916332

p_ni:  0.000083668

Score:  0.823

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

KEGG (2)

Find Similar Targets

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Phagosome	230 targets	path:hsa04145
KEGG	Tuberculosis	189 targets	path:hsa05152

Name	Explore in Pharos	Explore in Source
Phagosome	230 targets	path:hsa04145
Tuberculosis	189 targets	path:hsa05152

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (50)

Functions (9)

Components (17)

Processes (24)

Find Similar Targets

Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
actin filament binding	Inferred from Direct Assay (IDA)	UniProtKB
phosphatidylinositol 3-kinase binding	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
actin binding	Inferred from Physical Interaction (IPI)	UniProtKB
myosin heavy chain binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein C-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB
actin monomer binding	Inferred from Mutant Phenotype (IMP)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
cytoskeletal protein binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (16)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell density measurement	EFO_0007978	2	1	2		87.3
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		87
mean corpuscular volume	EFO_0004526	2	1	2		86
mean reticulocyte volume	EFO_0010701	1	1	1		85.6
eosinophil count	EFO_0004842	2	1	2		83.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell density measurement	EFO_0007978	2		87.3
mean corpuscular hemoglobin concentration	EFO_0004528	1		87
mean corpuscular volume	EFO_0004526	2		86
mean reticulocyte volume	EFO_0010701	1		85.6
eosinophil count	EFO_0004842	2		83.7

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Actin-binding
Coiled coil
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Direct protein sequencing
Disease mutation
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
body mass index
diastolic blood pressure
eosinophil count
erythrocyte count
hematocrit
hemoglobin measurement
Hodgkins lymphoma
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean platelet volume

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
immune system phenotype
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	coronin 1A	VGNC:8972	454038
Macaque	coronin 1A		710813
Mouse	coronin, actin binding protein 1A	MGI:1345961	12721
Rat	coronin 1A	RGD:620009	155151
Dog	coronin 1A	VGNC:39527	489949

Species	Name	OMA	EggNOG	Inparanoid
Chimp	coronin 1A
Macaque	coronin 1A
Mouse	coronin, actin binding protein 1A
Rat	coronin 1A
Dog	coronin 1A

Publication Statistics

PubMed Score 130.77

PubMed score by year

Reset Zoom

PubTator Score 90.64

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (51)

GeneRif Annotations (27)

Items per page:

10

0 of 0

PMID	Year	Title