Protein Summary
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
- ENST00000219150
- ENSP00000219150
- ENSG00000102879
- ENST00000570045
- ENSP00000455552
- CORO1
- p57
- IMD8
- TACO
- CLABP
- HCORO1
- CLIPINA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.97 | ||
biological process | 0.96 | ||
gene perturbation | 0.95 | ||
transcription factor perturbation | 0.88 | ||
small molecule perturbation | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 130.77 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 427 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 130.77 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 427 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 33
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (128)
POC1A
Novelty: 0.03897985
p_int: 0.999999921
p_ni: 7.9e-8
Score: 0.665
Data Source: BioPlex,STRINGDB
POC1B
Novelty: 0.09023863
p_int: 0.99999988
p_ni: 1.2e-7
Score: 0.813
Data Source: BioPlex,STRINGDB
TJAP1
Novelty: 0.008967
p_int: 0.999999707
p_ni: 1.89e-7
p_wrong: 1.04e-7
Score: 0.211
Data Source: BioPlex,STRINGDB
RABGAP1
Family: Enzyme
Novelty: 0.14270101
p_int: 0.999999693
p_ni: 3.07e-7
Score: 0.161
Data Source: BioPlex,STRINGDB
IFT80
Novelty: 0.04862973
p_int: 0.999998933
p_ni: 0.000001062
p_wrong: 5e-9
Score: 0.825
Data Source: BioPlex,STRINGDB
B7ZAP0
Family: Enzyme
Novelty: 0.2377644
p_int: 0.999956616
p_ni: 0.000043384
Score: 0.166
Data Source: BioPlex,STRINGDB
CORO1C
Novelty: 0.02068813
p_int: 0.999916332
p_ni: 0.000083668
Score: 0.823
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
KEGG (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Phagosome | ||||
KEGG | Tuberculosis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Phagosome | ||||
Tuberculosis | ||||
Viral Interactions (0)
Gene Ontology Terms (50)
Functions (9)
Components (17)
Processes (24)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
red blood cell density measurement | 2 | 1 | 2 | 87.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 87 | |||||
mean corpuscular volume | 2 | 1 | 2 | 86 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 85.6 | |||||
eosinophil count | 2 | 1 | 2 | 83.7 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
red blood cell density measurement | 2 | 87.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 87 | |||||
mean corpuscular volume | 2 | 86 | |||||
mean reticulocyte volume | 1 | 85.6 | |||||
eosinophil count | 2 | 83.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | coronin 1A | VGNC:8972 | 454038 | |||||
Macaque | coronin 1A | 710813 | ||||||
Mouse | MGI:1345961 | 12721 | ||||||
Rat | RGD:620009 | 155151 | ||||||
Dog | coronin 1A | VGNC:39527 | 489949 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | coronin 1A | |||||
Macaque | coronin 1A | |||||
Mouse | ||||||
Rat | ||||||
Dog | coronin 1A | |||||
Publication Statistics
PubMed Score 130.77
PubMed score by year
PubTator Score 90.64
PubTator score by year
Related Publications
Text Mined References (51)
GeneRif Annotations (27)
Items per page:
0 of 0
PMID | Year | Title |
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