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Tbio
CORO1A
Coronin-1A

Protein Summary
Description
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219150
  • ENSP00000219150
  • ENSG00000102879
  • ENST00000570045
  • ENSP00000455552

Symbol
  • CORO1
  • p57
  • IMD8
  • TACO
  • CLABP
  • HCORO1
  • CLIPINA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
biological process
0.96
gene perturbation
0.95
transcription factor perturbation
0.88
small molecule perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.77   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 427   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.77   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 427   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
CORO6
Tdark
Novelty:  0.37416507
p_int:  1
Score:  0.667
Data Source:  BioPlex,STRINGDB
IFT57
Tbio
Novelty:  0.03373199
p_int:  1
Score:  0.538
Data Source:  BioPlex,STRINGDB
POC1A
Tbio
Novelty:  0.03897985
p_int:  0.999999921
p_ni:  7.9e-8
Score:  0.665
Data Source:  BioPlex,STRINGDB
POC1B
Tbio
Novelty:  0.09023863
p_int:  0.99999988
p_ni:  1.2e-7
Score:  0.813
Data Source:  BioPlex,STRINGDB
TJAP1
Tbio
Novelty:  0.008967
p_int:  0.999999707
p_ni:  1.89e-7
p_wrong:  1.04e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
RABGAP1
Tbio
Family:  Enzyme
Novelty:  0.14270101
p_int:  0.999999693
p_ni:  3.07e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
IFT80
Tbio
Novelty:  0.04862973
p_int:  0.999998933
p_ni:  0.000001062
p_wrong:  5e-9
Score:  0.825
Data Source:  BioPlex,STRINGDB
B7ZAP0
Tbio
Family:  Enzyme
Novelty:  0.2377644
p_int:  0.999956616
p_ni:  0.000043384
Score:  0.166
Data Source:  BioPlex,STRINGDB
MATN2
Tbio
Novelty:  0.08506252
p_int:  0.999946269
p_ni:  0.000053731
Data Source:  BioPlex
CORO1C
Tbio
Novelty:  0.02068813
p_int:  0.999916332
p_ni:  0.000083668
Score:  0.823
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (50)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
2
1
2
87.3
mean corpuscular hemoglobin concentration
1
1
1
87
mean corpuscular volume
2
1
2
86
mean reticulocyte volume
1
1
1
85.6
eosinophil count
2
1
2
83.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
2
87.3
mean corpuscular hemoglobin concentration
1
87
mean corpuscular volume
2
86
mean reticulocyte volume
1
85.6
eosinophil count
2
83.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coronin 1A
VGNC:8972
454038
Macaque
coronin 1A
710813
Mouse
MGI:1345961
12721
Rat
RGD:620009
155151
Dog
coronin 1A
VGNC:39527
489949
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coronin 1A
Macaque
coronin 1A
Mouse
Rat
Dog
coronin 1A
Publication Statistics
PubMed Score 130.77
PubMed score by year
PubTator Score 90.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title