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Tbio
COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

Protein Summary
Description
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner. The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321998
  • ENSP00000322316
  • ENSG00000167186
  • ENST00000544894
  • ENSP00000442923
  • ENST00000568985
  • ENSP00000456734

Symbol
  • CAT5
  • CLK1
  • CLK-1
  • COQ10D8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.93
disease perturbation
0.9
histone modification site profile
0.81
cell type or tissue
0.79
gene perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.12   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.12   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
AARS2
Tbio
Family:  Enzyme
Novelty:  0.01309387
p_int:  0.860013062
p_ni:  0.139986938
Data Source:  BioPlex
COQ9
Tbio
Novelty:  0.00740475
Score:  0.997
Data Source:  Reactome,STRINGDB
COQ3
Tbio
Family:  Enzyme
Novelty:  0.03013258
Score:  0.996
Data Source:  STRINGDB
COQ5
Tbio
Family:  Enzyme
Novelty:  0.04664953
Score:  0.993
Data Source:  STRINGDB
COQ6
Tbio
Family:  Enzyme
Novelty:  0.0290336
Score:  0.968
Data Source:  STRINGDB
COQ4
Tbio
Novelty:  0.03537017
Score:  0.954
Data Source:  STRINGDB
COQ8A
Tbio
Family:  Kinase
Novelty:  0.01672738
Score:  0.934
Data Source:  STRINGDB
COQ8B
Tchem
Family:  Kinase
Novelty:  0.02469308
Score:  0.933
Data Source:  STRINGDB
COQ2
Tbio
Family:  Enzyme
Novelty:  0.00575853
Score:  0.909
Data Source:  STRINGDB
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of cofactors
Reactome
Metabolism of vitamins and cofactors
Reactome
Ubiquinol biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of cofactors
Metabolism of vitamins and cofactors
Ubiquinol biosynthesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
4.7
28.1
psychosis predisposition measurement
1
1
0
1.1
17.8
diastolic blood pressure
1
1
1
4.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
4.7
28.1
psychosis predisposition measurement
0
1.1
17.8
diastolic blood pressure
1
4.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coenzyme Q7, hydroxylase
VGNC:9076
740917
Macaque
coenzyme Q7, hydroxylase
693931
Mouse
MGI:107207
12850
Rat
RGD:2381
25249
Dog
coenzyme Q7, hydroxylase
VGNC:39522
479828
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coenzyme Q7, hydroxylase
Macaque
coenzyme Q7, hydroxylase
Mouse
Rat
Dog
coenzyme Q7, hydroxylase
Publication Statistics
PubMed Score 106.12
PubMed score by year
PubTator Score 24.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title