Tbio COQ3 Ubiquinone biosynthesis O-methyltransferase, mitochondrial

Protein Summary

Description

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9NZJ6
• B3KPX0
• Q5T061
• Q6P4F0
• Q8IXG6
• Q96BG1
• Q9H0N1

Gene Name

• COQ3

Ensembl ID

• ENST00000254759
• ENSP00000254759
• ENSG00000132423

Symbol

• DHHBMT
• bA9819.1
• DHHBMTASE
• UG0215E05

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
transcription factor perturbation	0.88
disease perturbation	0.87
gene perturbation	0.62
tissue	0.6

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Ubiquinone Biosynthesis O-methyltransferase, Mitochondrial

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Ubiquinone Biosynthesis O-methyltransferase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.57   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 160   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.57   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0