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Tbio
COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

Protein Summary
Description
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254759
  • ENSP00000254759
  • ENSG00000132423

Symbol
  • DHHBMT
  • bA9819.1
  • DHHBMTASE
  • UG0215E05
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor perturbation
0.88
disease perturbation
0.87
gene perturbation
0.62
tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.57   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.57   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
VPS28
Tbio
Novelty:  0.02927315
p_int:  0.992699375
p_ni:  0.007300624
p_wrong:  2e-9
Score:  0.316
Data Source:  BioPlex,STRINGDB
COQ6
Tbio
Family:  Enzyme
Novelty:  0.0290336
Score:  0.997
Data Source:  STRINGDB
COQ7
Tbio
Family:  Enzyme
Novelty:  0.01010794
Score:  0.996
Data Source:  STRINGDB
COQ4
Tbio
Novelty:  0.03537017
Score:  0.972
Data Source:  STRINGDB
COQ5
Tbio
Family:  Enzyme
Novelty:  0.04664953
Score:  0.969
Data Source:  STRINGDB
COQ2
Tbio
Family:  Enzyme
Novelty:  0.00575853
Score:  0.961
Data Source:  STRINGDB
COQ8A
Tbio
Family:  Kinase
Novelty:  0.01672738
Score:  0.959
Data Source:  STRINGDB
COQ9
Tbio
Novelty:  0.00740475
Score:  0.956
Data Source:  STRINGDB
PDSS1
Tbio
Family:  Enzyme
Novelty:  0.01542427
Score:  0.929
Data Source:  STRINGDB
COQ8B
Tchem
Family:  Kinase
Novelty:  0.02469308
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of cofactors
Reactome
Metabolism of vitamins and cofactors
Reactome
Ubiquinol biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of cofactors
Metabolism of vitamins and cofactors
Ubiquinol biosynthesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Genetic Interaction (IGI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
15.1
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coenzyme Q3, methyltransferase
VGNC:13013
472079
Mouse
MGI:101813
230027
Rat
RGD:2380
29309
Dog
coenzyme Q3, methyltransferase
VGNC:39518
475004
Horse
coenzyme Q3, methyltransferase
VGNC:16783
100071606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coenzyme Q3, methyltransferase
Mouse
Rat
Dog
coenzyme Q3, methyltransferase
Horse
coenzyme Q3, methyltransferase
Publication Statistics
PubMed Score 39.57
PubMed score by year
PubTator Score 4.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title