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Tbio
COPZ1
Coatomer subunit zeta-1

Protein Summary
Description
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262061
  • ENSP00000262061
  • ENSG00000111481
  • ENST00000455864
  • ENSP00000410620
  • ENST00000549043
  • ENSP00000449270
  • ENST00000552362
  • ENSP00000448444

Symbol
  • COPZ
  • COPZ
  • CGI-120
  • HSPC181
  • zeta-COP
  • zeta1-COP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
protein complex
1
disease perturbation
0.98
interacting protein
0.95
histone modification site profile
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.07   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.07   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (220)
COPB2
Tbio
Novelty:  0.02705751
p_int:  0.999329845
p_ni:  0.000670155
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
COPA
Tbio
Novelty:  0.02712824
p_int:  0.999157896
p_ni:  0.000842104
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
COPB1
Tbio
Novelty:  0.0078407
p_int:  0.999056502
p_ni:  0.000943498
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
p_int:  0.998231872
p_ni:  0.001768128
p_wrong:  1e-9
Data Source:  BioPlex
COPE
Tbio
Novelty:  0.02037359
p_int:  0.997287039
p_ni:  0.002712961
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
COPG1
Tbio
Novelty:  0.01331193
p_int:  0.994758774
p_ni:  0.005241212
p_wrong:  1.4e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ARCN1
Tbio
Novelty:  0.06716916
p_int:  0.989293197
p_ni:  0.010706803
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PPP1R10
Tbio
Family:  Enzyme
Novelty:  0.01119155
p_int:  0.969157347
p_ni:  0.030842574
p_wrong:  7.9e-8
Data Source:  BioPlex
COPG2
Tbio
Novelty:  0.06126837
p_int:  0.937439514
p_ni:  0.062560486
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SAFB2
Tbio
Novelty:  0.12354864
p_int:  0.936622267
p_ni:  0.063377372
p_wrong:  3.61e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
6
9
99.6
platelet count
8
5
8
6
99.1
red blood cell distribution width
4
2
6
93.4
mean corpuscular volume
1
2
2
85.7
reticulocyte measurement
2
2
2
78.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
99.6
platelet count
8
6
99.1
red blood cell distribution width
6
93.4
mean corpuscular volume
2
85.7
reticulocyte measurement
2
78.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coatomer protein complex subunit zeta 1
VGNC:5344
747268
Macaque
coatomer protein complex subunit zeta 1
705176
Mouse
MGI:1929063
56447
Rat
RGD:1306154
315345
Dog
coatomer protein complex subunit zeta 1
607013
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coatomer protein complex subunit zeta 1
Macaque
coatomer protein complex subunit zeta 1
Mouse
Rat
Dog
coatomer protein complex subunit zeta 1
Publication Statistics
PubMed Score 79.07
PubMed score by year
PubTator Score 19.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title