Tbio COPZ1 Coatomer subunit zeta-1

Protein Summary

Description

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• P61923
• B4DDX8
• B4DHZ0
• F8VS17
• F8VWL5
• Q549N6
• Q9Y3C3

Gene Name

• COPZ1

Ensembl ID

• ENST00000262061
• ENSP00000262061
• ENSG00000111481
• ENST00000455864
• ENSP00000410620
• ENST00000549043
• ENSP00000449270
• ENST00000552362
• ENSP00000448444

Symbol

• COPZ
• COPZ
• CGI-120
• HSPC181
• zeta-COP
• zeta1-COP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
protein complex	1
disease perturbation	0.98
interacting protein	0.95
histone modification site profile	0.85

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Vesicle Coat Protein / Coatomer Subunit Zeta-1

DTO Classes

Protein / Transporter / Vesicle Coat Protein / Coatomer Subunit Zeta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.07   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 200   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.07   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0