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Tbio
COPS8
COP9 signalosome complex subunit 8

Protein Summary
Description
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been sho ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354371
  • ENSP00000346340
  • ENSG00000198612
  • ENST00000392008
  • ENSP00000375865

Symbol
  • CSN8
  • COP9
  • CSN8
  • SGN8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.98
transcription factor binding site profile
0.92
transcription factor perturbation
0.91
histone modification site profile
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.69   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.69   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (279)
COPS3
Tbio
Novelty:  0.04664225
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS5
Tchem
Novelty:  0.00406225
p_int:  0.999999997
p_ni:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.999999996
p_ni:  4e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS6
Tbio
Novelty:  0.02653008
p_int:  0.999999993
p_ni:  7e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
DDB2
Tbio
Novelty:  0.00648809
p_int:  0.999999764
p_ni:  2.36e-7
Score:  0.986
Data Source:  BioPlex,STRINGDB
COPS7B
Tbio
Novelty:  0.63421506
p_int:  0.999999671
p_ni:  3.29e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
GPS1
Tbio
Novelty:  0.01433636
p_int:  0.999998449
p_ni:  0.000001551
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS7A
Tbio
Novelty:  0.02159233
p_int:  0.999991932
p_ni:  0.000008067
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS4
Tbio
Novelty:  0.04672417
p_int:  0.999991582
p_ni:  0.000008418
Score:  0.999
Data Source:  BioPlex,STRINGDB
LRR1
Tbio
Novelty:  0.02407468
p_int:  0.999985749
p_ni:  0.000013985
p_wrong:  2.66e-7
Score:  0.981
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Formation of TC-NER Pre-Incision Complex
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
DNA Damage Recognition in GG-NER
DNA Repair
Formation of TC-NER Pre-Incision Complex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
11.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
COP9 signalosome subunit 8
702097
Mouse
MGI:1915363
108679
Rat
RGD:1311404
363283
Dog
COP9 signalosome subunit 8
477417
Horse
COP9 signalosome subunit 8
VGNC:16778
100057535
Species
Name
OMA
EggNOG
Inparanoid
Macaque
COP9 signalosome subunit 8
Mouse
Rat
Dog
COP9 signalosome subunit 8
Horse
COP9 signalosome subunit 8
Publication Statistics
PubMed Score 26.69
PubMed score by year
PubTator Score 134.92
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title