Tbio COPS7A COP9 signalosome complex subunit 7a

Protein Summary

Description

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q9UBW8
• A8K9A6
• Q9NVX3
• Q9UJW4
• SGN7a

Gene Name

• COPS7A

Ensembl ID

• ENST00000229251
• ENSP00000229251
• ENSG00000111652
• ENST00000534877
• ENSP00000438363
• ENST00000534947
• ENSP00000446039
• ENST00000539735
• ENSP00000441852
• ENST00000543155
• ENSP00000438115

Symbol

• CSN7A
• DERP10
• CSN7
• CSN7A
• SGN7a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
disease perturbation	0.98
transcription factor binding site profile	0.92
histone modification site profile	0.89
transcription factor	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.08   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 200   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.08   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (281)

Explore Interacting Targets

1 – 10 of 281

• See Interactions on String-DB

COPS6

Tbio

Novelty:  0.02653008

p_int:  0.99999849

p_ni:  0.00000151

Score:  0.999

Data Source:  BioPlex,STRINGDB

COPS5

Tchem

Novelty:  0.00406225

p_int:  0.999996486

p_ni:  0.000003514

Score:  0.999

Data Source:  BioPlex,STRINGDB

COPS2

Tbio

Novelty:  0.03509351

p_int:  0.999995314

p_ni:  0.000004682

p_wrong:  3e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

COPS3

Tbio

Novelty:  0.04664225

p_int:  0.999992414

p_ni:  0.000007586

Score:  0.999

Data Source:  BioPlex,STRINGDB

COPS8

Tbio

Novelty:  0.0408885

p_int:  0.999991932

p_ni:  0.000008067

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

ANKRD39

Tdark

Novelty:  8.68843298

p_int:  0.99799059

p_ni:  0.002009407

p_wrong:  3e-9

Data Source:  BioPlex

KLHL10

Tdark

Novelty:  0.09497583

p_int:  0.997534008

p_ni:  0.00246599

p_wrong:  2e-9

Score:  0.6

Data Source:  BioPlex,STRINGDB

BTBD1

Tbio

Novelty:  0.19772296

p_int:  0.996032926

p_ni:  0.003967074

Score:  0.979

Data Source:  BioPlex,STRINGDB

UBE2M

Tchem

Novelty:  0.02353106

p_int:  0.995540719

p_ni:  0.004459281

Score:  0.772

Data Source:  BioPlex,STRINGDB

DCAF11

Tbio

Novelty:  0.08318661

p_int:  0.994846899

p_ni:  0.005153101

Score:  0.974

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (14)

Reactome (13)

WikiPathways (1)

Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	DNA Damage Recognition in GG-NER	38 targets	R-HSA-5696394
Reactome	DNA Repair	306 targets	R-HSA-73894
Reactome	Formation of TC-NER Pre-Incision Complex	53 targets	R-HSA-6781823

Name	Explore in Pharos	Explore in Source
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
DNA Damage Recognition in GG-NER	38 targets	R-HSA-5696394
DNA Repair	306 targets	R-HSA-73894
Formation of TC-NER Pre-Incision Complex	53 targets	R-HSA-6781823

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Components (3)

Processes (5)

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1 – 3 of 3

GO Term	Evidence	Assigned by
COP9 signalosome	Inferred from Direct Assay (IDA)	UniProtKB
cytosol	Inferred from Direct Assay (IDA)	HPA
nucleoplasm	Inferred from Direct Assay (IDA)	HPA

Disease Associations (null)

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	5	2	9		86.1
triglyceride measurement	EFO_0004530	1	1	1		53.3
insomnia measurement	EFO_0007876	1	1	0	1.1	46.9
red blood cell density measurement	EFO_0007978	1	1	1		44.2
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		44.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	9		86.1
triglyceride measurement	EFO_0004530	1		53.3
insomnia measurement	EFO_0007876	0	1.1	46.9
red blood cell density measurement	EFO_0007978	1		44.2
apolipoprotein A 1 measurement	EFO_0004614	1		44.2

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UniProt Keyword Find Similar Targets

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3D-structure
Acetylation
Coiled coil
Complete proteome
Cytoplasm
Direct protein sequencing
Host-virus interaction
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
BMI-adjusted hip circumference
high density lipoprotein cholesterol measurement
insomnia measurement
red blood cell density measurement
sex hormone-binding globulin measurement
smoking status measurement
triglyceride measurement

MGI Phenotype Find Similar Targets

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cardiovascular system phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
nervous system phenotype
renal/urinary system phenotype
reproductive system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	COP9 signalosome subunit 7A	VGNC:5343	451792
Macaque	COP9 signalosome subunit 7A		713607
Mouse	COP9 signalosome subunit 7A	MGI:1349400	26894
Rat	COP9 signalosome subunit 7A	RGD:1310070	312710
Dog	COP9 signalosome subunit 7A	VGNC:39513	486722

Species	Name	OMA	EggNOG	Inparanoid
Chimp	COP9 signalosome subunit 7A
Macaque	COP9 signalosome subunit 7A
Mouse	COP9 signalosome subunit 7A
Rat	COP9 signalosome subunit 7A
Dog	COP9 signalosome subunit 7A

Publication Statistics

PubMed Score 47.08

PubMed score by year

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PubTator Score 4.41

PubTator score by year

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Related Publications

Text Mined References (24)

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PMID	Year	Title