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Tbio
COPS7A
COP9 signalosome complex subunit 7a

Protein Summary
Description
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229251
  • ENSP00000229251
  • ENSG00000111652
  • ENST00000534877
  • ENSP00000438363
  • ENST00000534947
  • ENSP00000446039
  • ENST00000539735
  • ENSP00000441852
  • ENST00000543155
  • ENSP00000438115

Symbol
  • CSN7A
  • DERP10
  • CSN7
  • CSN7A
  • SGN7a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.98
transcription factor binding site profile
0.92
histone modification site profile
0.89
transcription factor
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.08   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.08   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (281)
COPS6
Tbio
Novelty:  0.02653008
p_int:  0.99999849
p_ni:  0.00000151
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS5
Tchem
Novelty:  0.00406225
p_int:  0.999996486
p_ni:  0.000003514
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.999995314
p_ni:  0.000004682
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS3
Tbio
Novelty:  0.04664225
p_int:  0.999992414
p_ni:  0.000007586
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS8
Tbio
Novelty:  0.0408885
p_int:  0.999991932
p_ni:  0.000008067
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.99799059
p_ni:  0.002009407
p_wrong:  3e-9
Data Source:  BioPlex
KLHL10
Tdark
Novelty:  0.09497583
p_int:  0.997534008
p_ni:  0.00246599
p_wrong:  2e-9
Score:  0.6
Data Source:  BioPlex,STRINGDB
BTBD1
Tbio
Novelty:  0.19772296
p_int:  0.996032926
p_ni:  0.003967074
Score:  0.979
Data Source:  BioPlex,STRINGDB
UBE2M
Tchem
Novelty:  0.02353106
p_int:  0.995540719
p_ni:  0.004459281
Score:  0.772
Data Source:  BioPlex,STRINGDB
DCAF11
Tbio
Novelty:  0.08318661
p_int:  0.994846899
p_ni:  0.005153101
Score:  0.974
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Formation of TC-NER Pre-Incision Complex
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
DNA Damage Recognition in GG-NER
DNA Repair
Formation of TC-NER Pre-Incision Complex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
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Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
2
9
86.1
triglyceride measurement
1
1
1
53.3
insomnia measurement
1
1
0
1.1
46.9
red blood cell density measurement
1
1
1
44.2
apolipoprotein A 1 measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
9
86.1
triglyceride measurement
1
53.3
insomnia measurement
0
1.1
46.9
red blood cell density measurement
1
44.2
apolipoprotein A 1 measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
COP9 signalosome subunit 7A
VGNC:5343
451792
Macaque
COP9 signalosome subunit 7A
713607
Mouse
MGI:1349400
26894
Rat
RGD:1310070
312710
Dog
COP9 signalosome subunit 7A
VGNC:39513
486722
Species
Name
OMA
EggNOG
Inparanoid
Chimp
COP9 signalosome subunit 7A
Macaque
COP9 signalosome subunit 7A
Mouse
Rat
Dog
COP9 signalosome subunit 7A
Publication Statistics
PubMed Score 47.08
PubMed score by year
PubTator Score 4.41
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title