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Tbio
COPS6
COP9 signalosome complex subunit 6

Protein Summary
Description
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an im ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303904
  • ENSP00000304102
  • ENSG00000168090

Symbol
  • CSN6
  • HVIP
  • CSN6
  • MOV34-34KD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
interacting protein
0.96
co-expressed gene
0.94
virus perturbation
0.83
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.31   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.31   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (309)
COPS3
Tbio
Novelty:  0.04664225
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS5
Tchem
Novelty:  0.00406225
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS7B
Tbio
Novelty:  0.63421506
p_int:  0.999999993
p_ni:  7e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS8
Tbio
Novelty:  0.0408885
p_int:  0.999999993
p_ni:  7e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS7A
Tbio
Novelty:  0.02159233
p_int:  0.99999849
p_ni:  0.00000151
Score:  0.999
Data Source:  BioPlex,STRINGDB
BTBD1
Tbio
Novelty:  0.19772296
p_int:  0.999991722
p_ni:  0.000008278
Score:  0.962
Data Source:  BioPlex,STRINGDB
DDB2
Tbio
Novelty:  0.00648809
p_int:  0.999990769
p_ni:  0.000009231
Score:  0.98
Data Source:  BioPlex,STRINGDB
LRR1
Tbio
Novelty:  0.02407468
p_int:  0.999986458
p_ni:  0.000013539
p_wrong:  3e-9
Score:  0.974
Data Source:  BioPlex,STRINGDB
DCAF4
Tbio
Novelty:  0.24190895
p_int:  0.999977078
p_ni:  0.000022922
Score:  0.974
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (281)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Formation of TC-NER Pre-Incision Complex
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
DNA Damage Recognition in GG-NER
DNA Repair
Formation of TC-NER Pre-Incision Complex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
78.3
FEV/FEC ratio
1
1
1
62.5
body height
1
1
1
62.1
1
1
0
1.3
61
1
1
0
1.1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
78.3
FEV/FEC ratio
1
62.5
body height
1
62.1
0
1.3
61
0
1.1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
COP9 signalosome subunit 6
VGNC:4315
463587
Macaque
COP9 signalosome subunit 6
710667
Mouse
MGI:1349439
26893
Rat
RGD:1309919
304343
Dog
COP9 signalosome subunit 6
VGNC:39512
479738
Species
Name
OMA
EggNOG
Inparanoid
Chimp
COP9 signalosome subunit 6
Macaque
COP9 signalosome subunit 6
Mouse
Rat
Dog
COP9 signalosome subunit 6
Publication Statistics
PubMed Score 46.31
PubMed score by year
PubTator Score 20.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title