You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
COPG1
Coatomer subunit gamma-1

Protein Summary
Description
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314797
  • ENSP00000325002
  • ENSG00000181789

Symbol
  • COPG
  • COPG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
0.97
histone modification site profile
0.91
cellular component
0.73
protein complex
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.01   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.01   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (244)
COPA
Tbio
Novelty:  0.02712824
p_int:  0.999956043
p_ni:  0.000043957
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
COPB2
Tbio
Novelty:  0.02705751
p_int:  0.999947465
p_ni:  0.000052535
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
COPB1
Tbio
Novelty:  0.0078407
p_int:  0.99988785
p_ni:  0.00011215
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
COPZ2
Tdark
Novelty:  0.21561497
p_int:  0.99971372
p_ni:  0.00028628
Score:  0.984
Data Source:  BioPlex,Reactome,STRINGDB
ARCN1
Tbio
Novelty:  0.06716916
p_int:  0.99910116
p_ni:  0.00089884
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
COPE
Tbio
Novelty:  0.02037359
p_int:  0.999078155
p_ni:  0.000921845
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ERGIC2
Tbio
Novelty:  0.08610944
p_int:  0.998833609
p_ni:  0.001166391
Score:  0.47
Data Source:  BioPlex,STRINGDB
COPZ1
Tbio
Novelty:  0.01405958
p_int:  0.994758774
p_ni:  0.005241212
p_wrong:  1.4e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ATL2
Tbio
Novelty:  0.03633884
p_int:  0.984599071
p_ni:  0.015400929
Score:  0.161
Data Source:  BioPlex,STRINGDB
ERGIC3
Tbio
Novelty:  0.11095443
p_int:  0.982275488
p_ni:  0.017724512
Score:  0.364
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
9
10
92.2
body height
4
4
4
91.2
BMI-adjusted waist-hip ratio
1
3
3
61.4
waist-hip ratio
1
3
3
60.9
gait measurement
1
1
1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
92.2
body height
4
91.2
BMI-adjusted waist-hip ratio
3
61.4
waist-hip ratio
3
60.9
gait measurement
1
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coatomer protein complex subunit gamma 1
VGNC:6173
460683
Mouse
MGI:1858696
54161
Dog
coatomer protein complex subunit gamma 1
VGNC:39507
476517
Horse
coatomer protein complex subunit gamma 1
VGNC:52366
100050080
Cow
coatomer protein complex subunit gamma 1
VGNC:27596
338055
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coatomer protein complex subunit gamma 1
Mouse
Dog
coatomer protein complex subunit gamma 1
Horse
coatomer protein complex subunit gamma 1
Cow
coatomer protein complex subunit gamma 1
Publication Statistics
PubMed Score 77.01
PubMed score by year
PubTator Score 21.22
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title