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Tbio
COPE
Coatomer subunit epsilon

Protein Summary
Description
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262812
  • ENSP00000262812
  • ENSG00000105669
  • ENST00000349893
  • ENSP00000343134
  • ENST00000351079
  • ENSP00000345674

Symbol
  • epsilon-COP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.91
histone modification site profile
0.9
disease perturbation
0.87
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.78   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.78   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (228)
COPG1
Tbio
Novelty:  0.01331193
p_int:  0.999078155
p_ni:  0.000921845
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
COPZ1
Tbio
Novelty:  0.01405958
p_int:  0.997287039
p_ni:  0.002712961
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
COPZ2
Tdark
Novelty:  0.21561497
p_int:  0.793912577
p_ni:  0.206087423
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
COPB2
Tbio
Novelty:  0.02705751
Score:  0.999
Data Source:  Reactome,STRINGDB
ARCN1
Tbio
Novelty:  0.06716916
Score:  0.999
Data Source:  Reactome,STRINGDB
COPA
Tbio
Novelty:  0.02712824
Score:  0.999
Data Source:  Reactome,STRINGDB
COPB1
Tbio
Novelty:  0.0078407
Score:  0.999
Data Source:  Reactome,STRINGDB
COPG2
Tbio
Novelty:  0.06126837
Score:  0.997
Data Source:  Reactome,STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.964
Data Source:  STRINGDB
SEC13
Tbio
Novelty:  0.00709413
Score:  0.96
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
38.1
low density lipoprotein cholesterol measurement
1
1
1
34.9
apolipoprotein B measurement
1
1
1
32.7
triglyceride measurement
1
1
1
15.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
38.1
low density lipoprotein cholesterol measurement
1
34.9
apolipoprotein B measurement
1
32.7
triglyceride measurement
1
15.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coatomer protein complex subunit epsilon
VGNC:2381
455865
Macaque
coatomer protein complex subunit epsilon
719631
Mouse
MGI:1891702
59042
Rat
RGD:1306785
290659
Dog
coatomer protein complex subunit epsilon
VGNC:39506
476663
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coatomer protein complex subunit epsilon
Macaque
coatomer protein complex subunit epsilon
Mouse
Rat
Dog
coatomer protein complex subunit epsilon
Publication Statistics
PubMed Score 37.78
PubMed score by year
PubTator Score 1769.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title