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Tbio
COPB2
Coatomer subunit beta'

Protein Summary
Description
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). The Golgi coatomer complex (see MIM 601924) constitutes the coat of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333188
  • ENSP00000329419
  • ENSG00000184432
  • ENST00000507777
  • ENSP00000422295

Symbol
  • MCPH19
  • beta'-COP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
virus perturbation
0.99
disease perturbation
0.93
histone modification site profile
0.85
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.92   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.92   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (216)
COPG1
Tbio
Novelty:  0.01331193
p_int:  0.999947465
p_ni:  0.000052535
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
COPZ1
Tbio
Novelty:  0.01405958
p_int:  0.999329845
p_ni:  0.000670155
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
COPZ2
Tdark
Novelty:  0.21561497
p_int:  0.955900792
p_ni:  0.044099208
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
p_int:  0.813180464
p_ni:  0.186819536
Score:  0.187
Data Source:  BioPlex,STRINGDB
COPB1
Tbio
Novelty:  0.0078407
Score:  0.999
Data Source:  Reactome,STRINGDB
COPE
Tbio
Novelty:  0.02037359
Score:  0.999
Data Source:  Reactome,STRINGDB
COPA
Tbio
Novelty:  0.02712824
Score:  0.999
Data Source:  Reactome,STRINGDB
ARCN1
Tbio
Novelty:  0.06716916
Score:  0.999
Data Source:  Reactome,STRINGDB
COPG2
Tbio
Novelty:  0.06126837
Score:  0.999
Data Source:  Reactome,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
6
6
98.8
1
3
3
93.6
2
1
1
1.2
73.9
lobe attachment
1
1
1
70.2
lobe size
1
1
1
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
6
98.8
3
93.6
1
1.2
73.9
lobe attachment
1
70.2
lobe size
1
61
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coatomer protein complex subunit beta 2
VGNC:10038
460734
Macaque
coatomer protein complex subunit beta 2
717632
Mouse
MGI:1354962
50797
Dog
coatomer protein complex subunit beta 2
VGNC:39505
477088
Horse
coatomer protein complex subunit beta 2
VGNC:16769
100063990
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coatomer protein complex subunit beta 2
Macaque
coatomer protein complex subunit beta 2
Mouse
Dog
coatomer protein complex subunit beta 2
Horse
coatomer protein complex subunit beta 2
Publication Statistics
PubMed Score 47.92
PubMed score by year
PubTator Score 77.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title