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Tdark
COMTD1
Catechol O-methyltransferase domain-containing protein 1

Protein Summary
Description
Putative O-methyltransferase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372538
  • ENSP00000361616
  • ENSG00000165644
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
cell type or tissue
0.78
transcription factor
0.59
disease perturbation
0.56
PubMedID
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.64   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.64   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
IFRD1
Tbio
Novelty:  0.0279279
p_int:  0.99999912
p_ni:  8.8e-7
Score:  0.207
Data Source:  BioPlex,STRINGDB
USP28
Tchem
Family:  Enzyme
Novelty:  0.02432294
p_int:  0.999998691
p_ni:  0.000001309
Score:  0.184
Data Source:  BioPlex,STRINGDB
PHKA1
Tbio
Family:  Kinase
Novelty:  0.02895127
p_int:  0.999989525
p_ni:  0.000010475
Score:  0.307
Data Source:  BioPlex,STRINGDB
PRMT9
Tbio
Family:  Enzyme
Novelty:  0.26898134
p_int:  0.999984284
p_ni:  0.000015715
p_wrong:  1e-9
Score:  0.203
Data Source:  BioPlex,STRINGDB
WAPL
Tbio
Novelty:  0.01598061
p_int:  0.999974898
p_ni:  0.000025102
Data Source:  BioPlex
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.999941191
p_ni:  0.000058809
Data Source:  BioPlex
MIGA1
Tbio
Novelty:  0.08346483
p_int:  0.999824305
p_ni:  0.000175695
Data Source:  BioPlex
PHKG2
Tchem
Family:  Kinase
Novelty:  0.064884
p_int:  0.999808391
p_ni:  0.000136402
p_wrong:  0.000055207
Data Source:  BioPlex
SUGP1
Tbio
Novelty:  0.00434166
p_int:  0.999784689
p_ni:  0.000215256
p_wrong:  5.5e-8
Data Source:  BioPlex
XPO4
Tbio
Novelty:  0.01507446
p_int:  0.99973424
p_ni:  0.00026576
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
8.9
smoking initiation
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
8.9
smoking initiation
1
5.8
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
catechol-O-methyltransferase domain containing 1
704152
Mouse
MGI:1916406
69156
Rat
RGD:1306581
305685
Dog
catechol-O-methyltransferase domain containing 1
VGNC:39502
489057
Horse
catechol-O-methyltransferase domain containing 1
VGNC:16766
100072941
Species
Name
OMA
EggNOG
Inparanoid
Macaque
catechol-O-methyltransferase domain containing 1
Mouse
Rat
Dog
catechol-O-methyltransferase domain containing 1
Horse
catechol-O-methyltransferase domain containing 1
Publication Statistics
PubMed Score 1.64
PubMed score by year
PubTator Score 1.11
PubTator score by year
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Related Publications
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PMID
Year
Title