Pharos : Target Details

Tbio

Protein Summary

Description

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombosp ...more

Uniprot Accession IDs

Gene Name

COMP

Ensembl ID

ENST00000222271
ENSP00000222271
ENSG00000105664
ENST00000425807
ENSP00000403792

Symbol

MED
EDM1
EPD1
TSP5
PSACH
THBS5

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1

PubMedID	0.83

molecular function	0.76

biological term	0.73

small molecule perturbation	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 696.29 (req: < 5)

View Publications

Gene RIFs: 100 (req: <= 3)

View Gene RIFs

Antibodies: 354 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 696.29 (req: >= 5)

Gene RIFs: 100 (req: > 3)

Antibodies: 354 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (101)

Explore Interacting Targets

1 – 10 of 101

See Interactions on String-DB

MATN2

Tbio

Novelty: 0.08506252

p_int: 0.999989256

p_ni: 0.000010744

Score: 0.599

Data Source: BioPlex,STRINGDB

MATN3

Tbio

Novelty: 0.00426202

Score: 0.983

Data Source: STRINGDB

ACAN

Tbio

Novelty: 0.00033695

Score: 0.981

Data Source: STRINGDB

MATN1

Tbio

Novelty: 0.00337153

Score: 0.969

Data Source: STRINGDB

MATN4

Tdark

Novelty: 0.31964843

Score: 0.966

Data Source: STRINGDB

CD47

Tchem

Novelty: 0.00129086

Score: 0.932