Tbio COMMD5 COMM domain-containing protein 5

Protein Summary

Description

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).

Uniprot Accession IDs

• Q9GZQ3
• D3DWN7
• Q9NVN6
• Q9UHX5

Gene Name

• COMMD5

Ensembl ID

• ENST00000305103
• ENSP00000304544
• ENSG00000170619
• ENST00000402718
• ENSP00000385793
• ENST00000450361
• ENSP00000394331
• ENST00000543949
• ENSP00000445840

Symbol

• HCARG
• HT002

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
kinase perturbation	0.71
tissue sample	0.66
cell type or tissue	0.61
histone modification site profile	0.55

Protein Classes

PANTHER Classes

Protein / Calcium-binding Protein / Comm Domain-containing Protein 5

DTO Classes

Protein / Calcium-binding Protein / Comm Domain-containing Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.4   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 35   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.4   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0