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Tbio
COMMD5
COMM domain-containing protein 5

Protein Summary
Description
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305103
  • ENSP00000304544
  • ENSG00000170619
  • ENST00000402718
  • ENSP00000385793
  • ENST00000450361
  • ENSP00000394331
  • ENST00000543949
  • ENSP00000445840

Symbol
  • HCARG
  • HT002
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
kinase perturbation
0.71
tissue sample
0.66
cell type or tissue
0.61
histone modification site profile
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.4   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.4   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0