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Tbio
COMMD4
COMM domain-containing protein 4

Protein Summary
Description
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267935
  • ENSP00000267935
  • ENSG00000140365
  • ENST00000338995
  • ENSP00000340867
  • ENST00000480484
  • ENSP00000433662
  • ENST00000567195
  • ENSP00000457693
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor perturbation
0.91
tissue sample
0.63
tissue
0.6
cell line
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.65   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.65   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (218)
COMMD8
Tdark
Novelty:  0.33240242
p_int:  1
Score:  0.994
Data Source:  BioPlex,STRINGDB
COMMD3
Tbio
Novelty:  0.07399068
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
COMMD10
Tbio
Novelty:  0.29057641
p_int:  1
Score:  0.992
Data Source:  BioPlex,STRINGDB
COMMD1
Tbio
Novelty:  0.01349432
p_int:  1
Score:  0.992
Data Source:  BioPlex,STRINGDB
COMMD6
Tbio
Novelty:  0.11854363
p_int:  0.999999999
p_ni:  1e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
COMMD2
Tdark
Novelty:  0.62195903
p_int:  0.999999997
p_ni:  3e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
CCDC22
Tbio
Novelty:  0.01400901
p_int:  0.999999991
p_ni:  9e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
FAM45A
Tdark
Novelty:  0.94034891
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.866
Data Source:  BioPlex,STRINGDB
COMMD9
Tdark
Novelty:  0.77223999
p_int:  0.999999586
p_ni:  4.14e-7
Score:  0.994
Data Source:  BioPlex,STRINGDB
COMMD5
Tbio
Novelty:  0.16163787
p_int:  0.999999384
p_ni:  5.87e-7
p_wrong:  2.8e-8
Score:  0.994
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
4
4
90.9
mean platelet volume
2
2
2
87
creatinine measurement
2
2
3
76.1
urate measurement
2
2
2
71.5
urinary albumin to creatinine ratio
1
1
1
21.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
90.9
mean platelet volume
2
87
creatinine measurement
3
76.1
urate measurement
2
71.5
urinary albumin to creatinine ratio
1
21.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
COMM domain containing 4
VGNC:2474
453757
Macaque
COMM domain-containing protein 4
712324
Mouse
MGI:1913449
66199
Rat
RGD:1306104
363068
Dog
COMM domain containing 4
VGNC:39495
612915
Species
Name
OMA
EggNOG
Inparanoid
Chimp
COMM domain containing 4
Macaque
COMM domain-containing protein 4
Mouse
Rat
Dog
COMM domain containing 4
Publication Statistics
PubMed Score 5.65
PubMed score by year
PubTator Score 0.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title