Protein Summary
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease. This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and remov ...more
- ENST00000400256
- ENSP00000383115
- ENSG00000158270
- CLP1
- NSR2
- SCARA4
- SRCL
- CLP1
- NSR2
- SRCL
- SCARA4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.9 | ||
cellular component | 0.74 | ||
protein domain | 0.73 | ||
tissue sample | 0.73 | ||
molecular function | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.82 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 207 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.82 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 207 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (81)
SCARA3
Novelty: 0.00621523
p_int: 0.999999999
p_ni: 1e-9
Score: 0.27
Data Source: BioPlex,STRINGDB
LGALS3
Novelty: 0.00032754
p_int: 0.999989813
p_ni: 0.000010187
Score: 0.237
Data Source: BioPlex,STRINGDB
ZC4H2
Novelty: 0.04969464
p_int: 0.999989625
p_ni: 0.00000183
p_wrong: 0.000008544
Score: 0.183
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (6)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | Immune System | ||||
Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Reactome | Scavenging by Class A Receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Immune System | ||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Scavenging by Class A Receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (5)
Components (6)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 72.5 | |||||
triglyceride measurement | 2 | 2 | 2 | 37.3 | |||||
blood protein measurement | 1 | 1 | 1 | 36.9 | |||||
coenzyme Q10 measurement | 1 | 1 | 1 | 24.5 | |||||
red blood cell distribution width | 2 | 1 | 2 | 13.1 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 1 | 72.5 | |||||
triglyceride measurement | 2 | 37.3 | |||||
blood protein measurement | 1 | 36.9 | |||||
coenzyme Q10 measurement | 1 | 24.5 | |||||
red blood cell distribution width | 2 | 13.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | collectin subfamily member 12 | VGNC:13250 | 468616 | |||||
Macaque | collectin subfamily member 12 | 700031 | ||||||
Mouse | MGI:2152907 | 140792 | ||||||
Rat | RGD:735039 | 361289 | ||||||
Dog | collectin subfamily member 12 | VGNC:39490 | 607342 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | collectin subfamily member 12 | |||||
Macaque | collectin subfamily member 12 | |||||
Mouse | ||||||
Rat | ||||||
Dog | collectin subfamily member 12 | |||||
Publication Statistics
PubMed Score 33.82
PubMed score by year
PubTator Score 94.09
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (12)
Items per page:
0 of 0
PMID | Year | Title |
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