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Tbio
COLEC12
Collectin-12

Protein Summary
Description
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease. This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and remov ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400256
  • ENSP00000383115
  • ENSG00000158270

Symbol
  • CLP1
  • NSR2
  • SCARA4
  • SRCL
  • CLP1
  • NSR2
  • SRCL
  • SCARA4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.9
cellular component
0.74
protein domain
0.73
tissue sample
0.73
molecular function
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.82   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.82   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
SCARA3
Tbio
Novelty:  0.00621523
p_int:  0.999999999
p_ni:  1e-9
Score:  0.27
Data Source:  BioPlex,STRINGDB
LAIR2
Tbio
Novelty:  0.06117644
p_int:  0.999998731
p_ni:  0.000001269
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.999989813
p_ni:  0.000010187
Score:  0.237
Data Source:  BioPlex,STRINGDB
ZC4H2
Tbio
Novelty:  0.04969464
p_int:  0.999989625
p_ni:  0.00000183
p_wrong:  0.000008544
Score:  0.183
Data Source:  BioPlex,STRINGDB
PDZK1P1
Tdark
p_int:  0.999986112
p_ni:  0.000013888
Data Source:  BioPlex
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999881452
p_ni:  0.000118548
Data Source:  BioPlex
FRMD3
Tbio
Novelty:  0.07186065
p_int:  0.999869053
p_ni:  0.000130947
Data Source:  BioPlex
TMX1
Tbio
Novelty:  0.03444237
p_int:  0.999734872
p_ni:  0.000265128
Data Source:  BioPlex
CGRRF1
Tdark
Novelty:  0.49690187
p_int:  0.999037532
p_ni:  0.000962468
Data Source:  BioPlex
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.998472116
p_ni:  0.001527884
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Scavenging by Class A Receptors
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Binding and Uptake of Ligands by Scavenger Receptors
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Scavenging by Class A Receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
72.5
triglyceride measurement
2
2
2
37.3
blood protein measurement
1
1
1
36.9
coenzyme Q10 measurement
1
1
1
24.5
red blood cell distribution width
2
1
2
13.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
72.5
triglyceride measurement
2
37.3
blood protein measurement
1
36.9
coenzyme Q10 measurement
1
24.5
red blood cell distribution width
2
13.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collectin subfamily member 12
VGNC:13250
468616
Macaque
collectin subfamily member 12
700031
Mouse
MGI:2152907
140792
Rat
RGD:735039
361289
Dog
collectin subfamily member 12
VGNC:39490
607342
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collectin subfamily member 12
Macaque
collectin subfamily member 12
Mouse
Rat
Dog
collectin subfamily member 12
Publication Statistics
PubMed Score 33.82
PubMed score by year
PubTator Score 94.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title