You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
COLEC11
Collectin-11

Protein Summary
Description
Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:23954398, PubMed:25912189, PubMed:21258343). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236693
  • ENSP00000236693
  • ENSG00000118004
  • ENST00000349077
  • ENSP00000339168
  • ENST00000382062
  • ENSP00000371494
  • ENST00000402794
  • ENSP00000384882
  • ENST00000402922
  • ENSP00000385653
  • ENST00000403096
  • ENSP00000385130
  • ENST00000404205
  • ENSP00000385827
  • ENST00000418971
  • ENSP00000411770

Symbol
  • 3MC2
  • CLK1
  • CL-K1-I
  • CL-K1-II
  • CL-K1-IIa
  • CL-K1-IIb
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.74
protein domain
0.73
cell line
0.63
tissue sample
0.63
tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.92   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.92   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
TRIM68
Tbio
Family:  Enzyme
Novelty:  0.11729189
p_int:  0.992072553
p_ni:  0.007927153
p_wrong:  2.94e-7
Score:  0.185
Data Source:  BioPlex,STRINGDB
NELL2
Tbio
Family:  Enzyme
Novelty:  0.03760438
p_int:  0.97244056
p_ni:  0.027495563
p_wrong:  0.000063877
Score:  0.541
Data Source:  BioPlex,STRINGDB
TIMP3
Tbio
Family:  Enzyme
Novelty:  0.00134742
p_int:  0.958797068
p_ni:  0.014264914
p_wrong:  0.026938018
Score:  0.173
Data Source:  BioPlex,STRINGDB
COL6A1
Tbio
Novelty:  0.00644855
p_int:  0.908239182
p_ni:  0.091760818
Score:  0.186
Data Source:  BioPlex,STRINGDB
RPL23
Tbio
Novelty:  0.02741113
p_int:  0.903668345
p_ni:  0.096331655
Data Source:  BioPlex
COLGALT2
Tbio
Family:  Enzyme
Novelty:  0.15981994
p_int:  0.89954511
p_ni:  0.10045489
Score:  0.178
Data Source:  BioPlex,STRINGDB
MTFR1
Tbio
Novelty:  0.14089765
p_int:  0.832213084
p_ni:  0.163809338
p_wrong:  0.003977578
Score:  0.189
Data Source:  BioPlex,STRINGDB
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.81562084
p_ni:  0.033347833
p_wrong:  0.151031327
Score:  0.177
Data Source:  BioPlex,STRINGDB
MASP1
Tchem
Family:  Enzyme
Novelty:  0.0029019
Score:  0.976
Data Source:  Reactome,STRINGDB
FCN3
Tbio
Novelty:  0.00771958
Score:  0.973
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Immune System
Reactome
Initial triggering of complement
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Complement cascade
Creation of C4 and C2 activators
Immune System
Initial triggering of complement
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
82.9
low density lipoprotein cholesterol measurement
4
4
4
78.2
high density lipoprotein cholesterol measurement
3
2
3
77.8
apolipoprotein A 1 measurement
2
2
2
75
viral load
1
1
1
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
82.9
low density lipoprotein cholesterol measurement
4
78.2
high density lipoprotein cholesterol measurement
3
77.8
apolipoprotein A 1 measurement
2
75
viral load
1
67.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collectin subfamily member 11
VGNC:209
743061
Macaque
collectin subfamily member 11
707223
Mouse
MGI:1918943
71693
Rat
RGD:1309678
366588
Dog
collectin subfamily member 11
VGNC:39489
482958
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collectin subfamily member 11
Macaque
collectin subfamily member 11
Mouse
Rat
Dog
collectin subfamily member 11
Publication Statistics
PubMed Score 35.92
PubMed score by year
PubTator Score 13.70
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title