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Tbio
COLEC11
Collectin-11

Protein Summary
Description
Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:23954398, PubMed:25912189, PubMed:21258343). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236693
  • ENSP00000236693
  • ENSG00000118004
  • ENST00000349077
  • ENSP00000339168
  • ENST00000382062
  • ENSP00000371494
  • ENST00000402794
  • ENSP00000384882
  • ENST00000402922
  • ENSP00000385653
  • ENST00000403096
  • ENSP00000385130
  • ENST00000404205
  • ENSP00000385827
  • ENST00000418971
  • ENSP00000411770

Symbol
  • 3MC2
  • CLK1
  • CL-K1-I
  • CL-K1-II
  • CL-K1-IIa
  • CL-K1-IIb
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.74
protein domain
0.73
cell line
0.63
tissue sample
0.63
tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.26   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.26   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0