Protein Summary
Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine (PubMed:10224141). Acts as a chemoattractant, probably involved in the regulation of cell migration (PubMed:28301481). This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins. [provided by RefSeq, Jul 2008]
- ENST00000332843
- ENSP00000332723
- ENSG00000184374
- CLL1
- 3MC3
- CLL1
- CL-34
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.77 | ||
protein domain | 0.73 | ||
phenotype | 0.54 | ||
cell type or tissue | 0.51 | ||
cell line | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.63 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 114 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.63 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 114 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (43)
PTX3
Novelty: 0.00153752
p_int: 0.9999762
p_ni: 0.000023799
p_wrong: 1e-9
Score: 0.293
Data Source: BioPlex,STRINGDB
INHBE
Novelty: 0.07526145
p_int: 0.999854759
p_ni: 0.000109886
p_wrong: 0.000035354
Score: 0.27
Data Source: BioPlex,STRINGDB
DCP2
Family: Enzyme
Novelty: 0.00661786
p_int: 0.995120427
p_ni: 0.004251126
p_wrong: 0.000628447
Score: 0.2
Data Source: BioPlex,STRINGDB
NUCB2
Novelty: 0.00831106
p_int: 0.946306527
p_ni: 0.053693473
Score: 0.237
Data Source: BioPlex,STRINGDB
TIMP3
Family: Enzyme
Novelty: 0.00134742
p_int: 0.934144924
p_ni: 0.065767969
p_wrong: 0.000087106
Score: 0.179
Data Source: BioPlex,STRINGDB
P3H4
Novelty: 0.08407419
p_int: 0.82170884
p_ni: 0.17829116
Score: 0.188
Data Source: BioPlex,STRINGDB
COLGALT2
Family: Enzyme
Novelty: 0.15981994
p_int: 0.752132494
p_ni: 0.247867506
Data Source: BioPlex
Nearest Tclin Targets
Pathways (6)
Reactome (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Complement cascade | ||||
Reactome | Creation of C4 and C2 activators | ||||
Reactome | Immune System | ||||
Reactome | Initial triggering of complement | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Complement cascade | ||||
Creation of C4 and C2 activators | ||||
Immune System | ||||
Initial triggering of complement | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (4)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
osteoprotegerin measurement | 2 | 5 | 5 | 98.9 | |||||
bone density | 12 | 9 | 14 | 97.2 | |||||
heel bone mineral density | 3 | 6 | 9 | 96.7 | |||||
alkaline phosphatase measurement | 3 | 2 | 2 | 19.5 | 95.5 | ||||
TNF-related activation-induced cytokine measurement | 1 | 1 | 1 | 86.2 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
osteoprotegerin measurement | 5 | 98.9 | |||||
bone density | 14 | 97.2 | |||||
heel bone mineral density | 9 | 96.7 | |||||
alkaline phosphatase measurement | 2 | 19.5 | 95.5 | ||||
TNF-related activation-induced cytokine measurement | 1 | 86.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | collectin subfamily member 10 | 701960 | ||||||
Mouse | MGI:3606482 | 239447 | ||||||
Rat | RGD:1307149 | 299928 | ||||||
Dog | collectin subfamily member 10 | VGNC:39488 | 608976 | |||||
Horse | collectin subfamily member 10 | VGNC:16754 | 100065958 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | collectin subfamily member 10 | |||||
Mouse | ||||||
Rat | ||||||
Dog | collectin subfamily member 10 | |||||
Horse | collectin subfamily member 10 | |||||
Publication Statistics
PubMed Score 40.63
PubMed score by year
PubTator Score 29.06
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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