Tbio COLEC10 Collectin-10

Protein Summary

Description

Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine (PubMed:10224141). Acts as a chemoattractant, probably involved in the regulation of cell migration (PubMed:28301481). This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y6Z7
• Q3SYH6
• Q6UW19

Gene Name

• COLEC10

Ensembl ID

• ENST00000332843
• ENSP00000332723
• ENSG00000184374

Symbol

• CLL1
• 3MC3
• CLL1
• CL-34

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.77
protein domain	0.73
phenotype	0.54
cell type or tissue	0.51
cell line	0.47

Protein Classes

PANTHER Classes

Protein / Surfactant / Collectin-10

Protein / Defense/immunity Protein / Collectin-10

DTO Classes

Protein / Surfactant / Collectin-10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.63   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.63   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (43)

Explore Interacting Targets

1 – 10 of 43

• See Interactions on String-DB

PTX3

Tbio

Novelty:  0.00153752

p_int:  0.9999762

p_ni:  0.000023799

p_wrong:  1e-9

Score:  0.293

Data Source:  BioPlex,STRINGDB

INHBE

Tbio

Novelty:  0.07526145

p_int:  0.999854759

p_ni:  0.000109886

p_wrong:  0.000035354

Score:  0.27

Data Source:  BioPlex,STRINGDB

DCP2

Tbio

Family:  Enzyme

Novelty:  0.00661786

p_int:  0.995120427

p_ni:  0.004251126

p_wrong:  0.000628447

Score:  0.2

Data Source:  BioPlex,STRINGDB

NUCB2

Tbio

Novelty:  0.00831106

p_int:  0.946306527

p_ni:  0.053693473

Score:  0.237

Data Source:  BioPlex,STRINGDB

TIMP3

Tbio

Family:  Enzyme

Novelty:  0.00134742

p_int:  0.934144924

p_ni:  0.065767969

p_wrong:  0.000087106

Score:  0.179

Data Source:  BioPlex,STRINGDB

CKAP4

Tbio

Novelty:  0.02104039

p_int:  0.902032399

p_ni:  0.097967601

Data Source:  BioPlex

P3H4

Tbio

Novelty:  0.08407419

p_int:  0.82170884

p_ni:  0.17829116

Score:  0.188

Data Source:  BioPlex,STRINGDB

DNAJB9

Tbio

Novelty:  0.00536296

p_int:  0.809686377

p_ni:  0.190313623

Data Source:  BioPlex

COLGALT2

Tbio

Family:  Enzyme

Novelty:  0.15981994

p_int:  0.752132494

p_ni:  0.247867506

Data Source:  BioPlex

FCN2

Tbio

Novelty:  0.00519137

Score:  0.967

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (6)

Complement cascade (R-HSA-166658)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Complement cascade	133 targets	R-HSA-166658
Reactome	Creation of C4 and C2 activators	91 targets	R-HSA-166786
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Initial triggering of complement	98 targets	R-HSA-166663
Reactome	Innate Immune System	1188 targets	R-HSA-168249

Name	Explore in Pharos	Explore in Source
Complement cascade	133 targets	R-HSA-166658
Creation of C4 and C2 activators	91 targets	R-HSA-166786
Immune System	2246 targets	R-HSA-168256
Initial triggering of complement	98 targets	R-HSA-166663
Innate Immune System	1188 targets	R-HSA-168249

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (4)

Components (5)

Processes (3)

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1 – 4 of 4

GO Term	Evidence	Assigned by
chemoattractant activity	Inferred from Direct Assay (IDA)	UniProtKB
mannose binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
monosaccharide binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
serine-type endopeptidase activity	Traceable Author Statement (TAS)	Reactome

Disease Associations (null)

No disease associations found

GWAS Traits (24)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 24

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
osteoprotegerin measurement	EFO_0005918	2	5	5		98.9
bone density	EFO_0003923	12	9	14		97.2
heel bone mineral density	EFO_0009270	3	6	9		96.7
alkaline phosphatase measurement	EFO_0004533	3	2	2	19.5	95.5
TNF-related activation-induced cytokine measurement	EFO_0010929	1	1	1		86.2

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5

1 – 5 of 24

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
osteoprotegerin measurement	EFO_0005918	5		98.9
bone density	EFO_0003923	14		97.2
heel bone mineral density	EFO_0009270	9		96.7
alkaline phosphatase measurement	EFO_0004533	2	19.5	95.5
TNF-related activation-induced cytokine measurement	EFO_0010929	1		86.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Calcium
Collagen
Complete proteome
Cytoplasm
Disease mutation
Disulfide bond
Glycoprotein
Golgi apparatus
Lectin
Mannose-binding

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
aspartate aminotransferase measurement
basal cell carcinoma
blood protein measurement
bone density
childhood onset asthma
eosinophil count
eosinophil percentage of leukocytes
femoral neck bone mineral density
heel bone mineral density

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
craniofacial phenotype
growth/size/body region phenotype
limbs/digits/tail phenotype
nervous system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	collectin subfamily member 10		701960
Mouse	collectin sub-family member 10	MGI:3606482	239447
Rat	collectin subfamily member 10	RGD:1307149	299928
Dog	collectin subfamily member 10	VGNC:39488	608976
Horse	collectin subfamily member 10	VGNC:16754	100065958

Species	Name	OMA	EggNOG	Inparanoid
Macaque	collectin subfamily member 10
Mouse	collectin sub-family member 10
Rat	collectin subfamily member 10
Dog	collectin subfamily member 10
Horse	collectin subfamily member 10

Publication Statistics

PubMed Score 40.63

PubMed score by year

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PubTator Score 29.06

PubTator score by year

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Related Publications

Text Mined References (22)

GeneRif Annotations (7)

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10

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PMID	Year	Title