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Tbio
COL9A3
Collagen alpha-3(IX) chain

Protein Summary
Description
Structural component of hyaline cartilage and vitreous of the eye. This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. Mutations in this gene are associated with multiple epiphyseal dysplasia type 3. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343916
  • ENSP00000341640
  • ENSG00000092758
  • ENST00000649368
  • ENSP00000496793

Symbol
  • IDD
  • MED
  • EDM3
  • DJ885L7.4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.87
PubMedID
0.73
cell type or tissue
0.65
tissue sample
0.61
small molecule perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.03   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.03   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
COL9A2
Tbio
Novelty:  0.01711515
Score:  0.997
Data Source:  Reactome,STRINGDB
COL9A1
Tbio
Novelty:  0.0160066
Score:  0.995
Data Source:  Reactome,STRINGDB
COL2A1
Tbio
Novelty:  0.0011102
Score:  0.969
Data Source:  STRINGDB
COL11A1
Tbio
Novelty:  0.00594683
Score:  0.937
Data Source:  STRINGDB
COL11A2
Tbio
Novelty:  0.00923441
Score:  0.932
Data Source:  STRINGDB
MMP3
Tchem
Novelty:  0.00041675
Score:  0.928
Data Source:  STRINGDB
BGN
Tbio
Novelty:  0.00139486
Score:  0.925
Data Source:  STRINGDB
COL5A1
Tbio
Novelty:  0.00506815
Score:  0.925
Data Source:  STRINGDB
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
Score:  0.924
Data Source:  STRINGDB
COL10A1
Tbio
Novelty:  0.00521991
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Axon guidance
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen degradation
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Axon guidance
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen degradation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
1
1
59.8
monocyte count
1
1
1
48.5
age at menopause
1
1
1
42.3
diastolic blood pressure
1
1
1
24.5
waist circumference
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
59.8
monocyte count
1
48.5
age at menopause
1
42.3
diastolic blood pressure
1
24.5
waist circumference
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type IX alpha 3 chain
VGNC:13837
745218
Mouse
MGI:894686
12841
Rat
RGD:1310255
362285
Dog
collagen type IX alpha 3 chain
VGNC:39487
612430
Horse
collagen type IX alpha 3 chain
VGNC:16753
100058660
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type IX alpha 3 chain
Mouse
Rat
Dog
collagen type IX alpha 3 chain
Horse
collagen type IX alpha 3 chain
Publication Statistics
PubMed Score 38.03
PubMed score by year
PubTator Score 45.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title