Tbio COL6A5 Collagen alpha-5(VI) chain

Protein Summary

Description

Collagen VI acts as a cell-binding protein. This gene encodes a member of the collagen superfamily of proteins. The encoded protein contains multiple von Willebrand factor A-like domains and may interact with the alpha 1 and alpha 2 chains of collagen VI to form the complete collagen VI trimer. Polymorphisms in this gene may be linked to dermal phenotypes, such as eczema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• A8TX70
• A9J6L2
• A9J6L4
• A9J6L6
• A9J6L7
• A9J6M0
• A9J6M1
• A9J6M2
• B5MEA7
• Q6ZW26
• Q8NA36

Gene Name

• COL6A5

Ensembl ID

• ENST00000312481
• ENSP00000309762
• ENSG00000172752

Symbol

• COL29A1
• VWA4
• VWA4
• COL29A1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.66
cell type or tissue	0.63
cell line	0.55
transcription factor	0.54
gene perturbation	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.67   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.67   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0