You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
COL6A2
Collagen alpha-2(VI) chain

Protein Summary
Description
Collagen VI acts as a cell-binding protein. This gene encodes one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The product of this gene contains several domains similar to von Willebrand Factor type A domains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in this gene are associated with Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. Three transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300527
  • ENSP00000300527
  • ENSG00000142173
  • ENST00000310645
  • ENSP00000312529
  • ENST00000397763
  • ENSP00000380870
  • ENST00000409416
  • ENSP00000387115

Symbol
  • UCMD1
  • BTHLM1
  • PP3610
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
disease perturbation
0.79
kinase perturbation
0.76
phenotype
0.64
small molecule perturbation
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.11   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.11   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
MMP9
Tchem
Family:  Enzyme
Novelty:  0.00008645
p_int:  0.99996002
p_ni:  0.00003998
Score:  0.292
Data Source:  BioPlex,STRINGDB
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.999704147
p_ni:  0.000295853
Data Source:  BioPlex
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.99838354
p_ni:  0.00161646
Data Source:  BioPlex
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.997356095
p_ni:  0.002643905
Data Source:  BioPlex
C1QTNF9
Tbio
Novelty:  0.03485116
p_int:  0.995644649
p_ni:  0.004355351
Score:  0.194
Data Source:  BioPlex,STRINGDB
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.995638109
p_ni:  0.004361891
Data Source:  BioPlex
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.993470903
p_ni:  0.006529097
Data Source:  BioPlex
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
p_int:  0.992507715
p_ni:  0.007492284
Score:  0.919
Data Source:  BioPlex,STRINGDB
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.988917223
p_ni:  0.011082771
p_wrong:  6e-9
Data Source:  BioPlex
MMP2
Tchem
Family:  Enzyme
Novelty:  0.00012762
p_int:  0.986839594
p_ni:  0.013160406
Score:  0.735
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Axon guidance
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Axon guidance
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
2
2
61.8
corneal resistance factor
1
1
1
50.6
BMI-adjusted waist circumference
3
4
5
45.7
corneal topography
3
1
3
42.3
waist-hip ratio
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
61.8
corneal resistance factor
1
50.6
BMI-adjusted waist circumference
5
45.7
corneal topography
3
42.3
waist-hip ratio
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type VI alpha 2 chain
VGNC:14656
474056
Macaque
collagen type VI alpha 2 chain
709493
Mouse
MGI:88460
12834
Rat
RGD:1305585
361821
Horse
collagen type VI alpha 2 chain
VGNC:16747
100055332
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type VI alpha 2 chain
Macaque
collagen type VI alpha 2 chain
Mouse
Rat
Horse
collagen type VI alpha 2 chain
Publication Statistics
PubMed Score 71.11
PubMed score by year
PubTator Score 54.17
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title