COL4A6
Collagen alpha-6(IV) chain
Protein Summary
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
- ENST00000334504
- ENSP00000334733
- ENSG00000197565
- ENST00000372216
- ENSP00000361290
- DFNX6
- DELXq22.3
- CXDELq22.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.78 | ||
kinase perturbation | 0.71 | ||
tissue sample | 0.69 | ||
histone modification site profile | 0.63 | ||
cellular component | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.66 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 160 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.66 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 160 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (130)
PLOD1
Family: Enzyme
Novelty: 0.00905345
p_int: 0.999999981
p_ni: 1.6e-8
p_wrong: 4e-9
Score: 0.932
Data Source: BioPlex,STRINGDB
LAIR2
Novelty: 0.06117644
p_int: 0.999997546
p_ni: 0.000002092
p_wrong: 3.62e-7
Data Source: BioPlex
PLOD3
Family: Enzyme
Novelty: 0.02211629
p_int: 0.999941407
p_ni: 0.000002133
p_wrong: 0.000056459
Score: 0.92
Data Source: BioPlex,STRINGDB
FKBP9
Family: Enzyme
Novelty: 0.16472204
p_int: 0.999581134
p_ni: 0.000415945
p_wrong: 0.000002921
Score: 0.279
Data Source: BioPlex,STRINGDB
MMP2
Family: Enzyme
Novelty: 0.00012762
p_int: 0.891266364
p_ni: 0.00002707
p_wrong: 0.108706566
Score: 0.303
Data Source: BioPlex,STRINGDB
COL8A2
Novelty: 0.01672103
p_int: 0.807418797
p_ni: 0.000032069
p_wrong: 0.192549135
Score: 0.931
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (32)
Reactome (11)
KEGG (10)
PathwayCommons (6)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Attenuation phase | ||||
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Attenuation phase | ||||
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Collagen biosynthesis and modifying enzymes | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | collagen type IV alpha 6 chain | VGNC:10729 | 465804 | |||||
Macaque | collagen type IV alpha 6 chain | 703707 | ||||||
Mouse | MGI:2152695 | 94216 | ||||||
Dog | collagen type IV alpha 6 chain | VGNC:39477 | 403840 | |||||
Horse | collagen type IV alpha 6 chain | VGNC:16743 | 100060112 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | collagen type IV alpha 6 chain | |||||
Macaque | collagen type IV alpha 6 chain | |||||
Mouse | ||||||
Dog | collagen type IV alpha 6 chain | |||||
Horse | collagen type IV alpha 6 chain | |||||
Publication Statistics
PubMed Score 39.66
PubMed score by year
PubTator Score 33.78
PubTator score by year
Related Publications
Text Mined References (58)
GeneRif Annotations (22)
Items per page:
0 of 0
PMID | Year | Title |
|---|