COL4A4
Collagen alpha-4(IV) chain
Protein Summary
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR. [provided by RefSe ...more
- ENST00000396625
- ENSP00000379866
- ENSG00000081052
- BFH
- ATS2
- CA44
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.8 | ||
microRNA | 0.7 | ||
histone modification site profile | 0.66 | ||
tissue sample | 0.65 | ||
cellular component | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 120.98 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 66 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 120.98 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 66 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (137)
LAIR2
Novelty: 0.06117644
p_int: 0.995786517
p_ni: 1.13e-7
p_wrong: 0.00421337
Data Source: BioPlex
Nearest Tclin Targets
Pathways (35)
Reactome (13)
KEGG (10)
PathwayCommons (6)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Axon guidance | ||||
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Reactome | Collagen chain trimerization | ||||
Reactome | Collagen formation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Axon guidance | ||||
Collagen biosynthesis and modifying enzymes | ||||
Collagen chain trimerization | ||||
Collagen formation | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (1)
Components (6)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urinary microalbumin measurement | 1 | 1 | 1 | 81.7 | |||||
urinary albumin to creatinine ratio | 3 | 3 | 3 | 66.2 | |||||
albuminuria | 4 | 2 | 2 | 1.2 | 53.1 | ||||
3 | 1 | 0 | 1.3 | 52.7 | |||||
electrocardiography | 1 | 1 | 3 | 33.1 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urinary microalbumin measurement | 1 | 81.7 | |||||
urinary albumin to creatinine ratio | 3 | 66.2 | |||||
albuminuria | 2 | 1.2 | 53.1 | ||||
0 | 1.3 | 52.7 | |||||
electrocardiography | 3 | 33.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | collagen type IV alpha 4 chain | 708287 | ||||||
Mouse | MGI:104687 | 12829 | ||||||
Dog | collagen type IV alpha 4 chain | VGNC:39476 | 403841 | |||||
Horse | collagen type IV alpha 4 chain | VGNC:16741 | 100062160 | |||||
Cow | collagen type IV alpha 4 chain | VGNC:50083 | 407107 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | collagen type IV alpha 4 chain | |||||
Mouse | ||||||
Dog | collagen type IV alpha 4 chain | |||||
Horse | collagen type IV alpha 4 chain | |||||
Cow | collagen type IV alpha 4 chain | |||||
Publication Statistics
PubMed Score 120.98
PubMed score by year
PubTator Score 89.30
PubTator score by year
Related Publications
Text Mined References (93)
GeneRif Annotations (51)
Items per page:
0 of 0
PMID | Year | Title |
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