You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
COL4A2
Collagen alpha-2(IV) chain

Protein Summary
Description
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360467
  • ENSP00000353654
  • ENSG00000134871

Symbol
  • ICH
  • BSVD2
  • POREN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
0.91
gene perturbation
0.86
disease
0.83
kinase perturbation
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.66   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.66   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (172)
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
p_int:  0.999998756
p_ni:  0.000001244
Score:  0.937
Data Source:  BioPlex,STRINGDB
PLOD3
Tbio
Family:  Enzyme
Novelty:  0.02211629
p_int:  0.999940229
p_ni:  0.000059771
Score:  0.934
Data Source:  BioPlex,STRINGDB
COLGALT2
Tbio
Family:  Enzyme
Novelty:  0.15981994
p_int:  0.999863767
p_ni:  0.000136233
Score:  0.956
Data Source:  BioPlex,STRINGDB
MMP9
Tchem
Family:  Enzyme
Novelty:  0.00008645
p_int:  0.999269461
p_ni:  0.000730539
Score:  0.538
Data Source:  BioPlex,STRINGDB
LAIR2
Tbio
Novelty:  0.06117644
p_int:  0.999257175
p_ni:  0.000742825
Data Source:  BioPlex
MMP2
Tchem
Family:  Enzyme
Novelty:  0.00012762
p_int:  0.998648391
p_ni:  0.001351609
Score:  0.613
Data Source:  BioPlex,STRINGDB
FKBP9
Tbio
Family:  Enzyme
Novelty:  0.16472204
p_int:  0.972187907
p_ni:  0.027812093
Score:  0.303
Data Source:  BioPlex,STRINGDB
LYG2
Tbio
Family:  Enzyme
Novelty:  0.12091256
p_int:  0.939200586
p_ni:  0.060799414
Data Source:  BioPlex
C1QTNF2
Tbio
Novelty:  0.18607978
p_int:  0.916496763
p_ni:  0.083503236
Score:  0.276
Data Source:  BioPlex,STRINGDB
COL10A1
Tbio
Novelty:  0.00521991
p_int:  0.905750056
p_ni:  0.094249318
p_wrong:  6.26e-7
Score:  0.961
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (80)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Axon guidance
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Axon guidance
Binding and Uptake of Ligands by Scavenger Receptors
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (81)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
7
6
1.1
94.4
BMI-adjusted waist-hip ratio
5
7
8
88.7
low density lipoprotein cholesterol measurement
5
4
5
77.7
platelet crit
1
2
2
77.2
serum gamma-glutamyl transferase measurement
1
1
1
74.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
1.1
94.4
BMI-adjusted waist-hip ratio
8
88.7
low density lipoprotein cholesterol measurement
5
77.7
platelet crit
2
77.2
serum gamma-glutamyl transferase measurement
1
74.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type IV alpha 2 chain
VGNC:10710
452661
Mouse
MGI:88455
12827
Rat
RGD:1308085
306628
Dog
collagen type IV alpha 2 chain
VGNC:39474
403843
Horse
collagen type IV alpha 2 chain
VGNC:16739
100066264
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type IV alpha 2 chain
Mouse
Rat
Dog
collagen type IV alpha 2 chain
Horse
collagen type IV alpha 2 chain
Publication Statistics
PubMed Score 130.66
PubMed score by year
PubTator Score 72.61
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title