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Tbio
COL17A1
Collagen alpha-1(XVII) chain

Protein Summary
Description
May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353479
  • ENSP00000340937
  • ENSG00000065618
  • ENST00000369733
  • ENSP00000358748
  • ENST00000648076
  • ENSP00000497653

Symbol
  • BP180
  • BPAG2
  • ERED
  • BP180
  • BPA-2
  • BPAG2
  • LAD-1
  • BA16H23.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.69
cellular component
0.68
gene perturbation
0.58
cell type or tissue
0.53
disease
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 787.93   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 787.93   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
DST
Tbio
Novelty:  0.00238839
Score:  0.994
Data Source:  STRINGDB
PLEC
Tbio
Novelty:  0.00223244
Score:  0.984
Data Source:  Reactome,STRINGDB
ITGB4
Tbio
Novelty:  0.00386461
Score:  0.979
Data Source:  Reactome,STRINGDB
LAMB3
Tbio
Novelty:  0.00717673
Score:  0.971
Data Source:  Reactome,STRINGDB
LAMA3
Tbio
Novelty:  0.00733792
Score:  0.97
Data Source:  Reactome,STRINGDB
LAMC2
Tbio
Novelty:  0.00695692
Score:  0.967
Data Source:  Reactome,STRINGDB
ITGA6
Tbio
Novelty:  0.00217985
Score:  0.966
Data Source:  Reactome,STRINGDB
CD151
Tbio
Novelty:  0.00295527
Score:  0.955
Data Source:  Reactome,STRINGDB
ADAM9
Tchem
Family:  Enzyme
Novelty:  0.00616626
Score:  0.932
Data Source:  STRINGDB
COL7A1
Tbio
Novelty:  0.00232977
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen degradation
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen degradation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
2
2
60.4
1
1
0
1.2
26.6
1
1
0
1.5
12.7
mean corpuscular hemoglobin concentration
1
1
1
12.4
mean corpuscular hemoglobin
1
1
1
9.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
60.4
0
1.2
26.6
0
1.5
12.7
mean corpuscular hemoglobin concentration
1
12.4
mean corpuscular hemoglobin
1
9.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type XVII alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2194]
Mouse
MGI:88450
12821
Rat
RGD:1311130
294027
Dog
collagen type XVII alpha 1 chain
VGNC:39462
403739
Horse
collagen type XVII alpha 1 chain
VGNC:16727
100069671
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type XVII alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2194]
Mouse
Rat
Dog
collagen type XVII alpha 1 chain
Horse
collagen type XVII alpha 1 chain
Publication Statistics
PubMed Score 787.93
PubMed score by year
PubTator Score 543.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title