Tbio COL16A1 Collagen alpha-1(XVI) chain

Protein Summary

Description

Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology. This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q07092
• Q16593
• Q59F89
• Q71RG9

Gene Name

• COL16A1

Ensembl ID

• ENST00000373672
• ENSP00000362776
• ENSG00000084636

Symbol

• 447AA
• FP1572

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.76
gene perturbation	0.7
PubMedID	0.67
cell type or tissue	0.64
biological process	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.51   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 53   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.51   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0