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Tbio
COL16A1
Collagen alpha-1(XVI) chain

Protein Summary
Description
Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology. This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373672
  • ENSP00000362776
  • ENSG00000084636

Symbol
  • 447AA
  • FP1572
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.76
gene perturbation
0.7
PubMedID
0.67
cell type or tissue
0.64
biological process
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.51   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.51   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
COL4A1
Tbio
Novelty:  0.00358049
Score:  0.957
Data Source:  STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
Score:  0.95
Data Source:  STRINGDB
COL6A1
Tbio
Novelty:  0.00644855
Score:  0.949
Data Source:  STRINGDB
COL12A1
Tbio
Novelty:  0.0239421
Score:  0.946
Data Source:  STRINGDB
COL3A1
Tbio
Novelty:  0.00197327
Score:  0.944
Data Source:  STRINGDB
COL5A1
Tbio
Novelty:  0.00506815
Score:  0.944
Data Source:  STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
Score:  0.943
Data Source:  STRINGDB
COL5A3
Tbio
Novelty:  0.06365591
Score:  0.942
Data Source:  STRINGDB
COL6A2
Tbio
Novelty:  0.01275082
Score:  0.94
Data Source:  STRINGDB
COL5A2
Tbio
Novelty:  0.01352973
Score:  0.939
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen degradation
Reactome
Collagen formation
Reactome
Degradation of the extracellular matrix
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen degradation
Collagen formation
Degradation of the extracellular matrix
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
15
7
5.8
93.4
self reported educational attainment
3
3
2
6.1
85
educational attainment
1
3
3
83.7
cognitive function measurement
3
2
3
76.3
body mass index
3
3
3
60.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
7
5.8
93.4
self reported educational attainment
2
6.1
85
educational attainment
3
83.7
cognitive function measurement
3
76.3
body mass index
3
60.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
collagen type XVI alpha 1 chain
706149
Mouse
MGI:1095396
107581
Rat
RGD:1310982
366474
Dog
collagen type XVI alpha 1 chain
VGNC:39461
487318
Horse
collagen type XVI alpha 1 chain
VGNC:16726
100056083
Species
Name
OMA
EggNOG
Inparanoid
Macaque
collagen type XVI alpha 1 chain
Mouse
Rat
Dog
collagen type XVI alpha 1 chain
Horse
collagen type XVI alpha 1 chain
Publication Statistics
PubMed Score 9.51
PubMed score by year
PubTator Score 4.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title