Tbio COL14A1 Collagen alpha-1(XIV) chain

Protein Summary

Description

Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in the regulation of fibrillogenesis. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• Q05707
• B2RU07
• O00260
• O00261
• O00262
• Q05708
• Q5XJ18
• Q96C67
• Q9UDF6

Gene Name

• COL14A1

Ensembl ID

• ENST00000297848
• ENSP00000297848
• ENSG00000187955
• ENST00000309791
• ENSP00000311809

Symbol

• UND
• UND

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.98
PubMedID	0.97
protein domain	0.85
kinase perturbation	0.84
histone modification site profile	0.76

Protein Classes

PANTHER Classes

Protein / Receptor / Collagen Alpha-1(xiv) Chain

DTO Classes

Protein / Receptor / Collagen Alpha-1(xiv) Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.88   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.88   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (117)

Explore Interacting Targets

1 – 10 of 117

• See Interactions on String-DB

MMP9

Tchem

Family:  Enzyme

Novelty:  0.00008645

p_int:  0.999996994

p_ni:  0.000003006

Score:  0.928

Data Source:  BioPlex,STRINGDB

MMP2

Tchem

Family:  Enzyme

Novelty:  0.00012762

p_int:  0.999990076

p_ni:  0.000009924

Score:  0.444

Data Source:  BioPlex,STRINGDB

COL8A2

Tbio

Novelty:  0.01672103

p_int:  0.999824585

p_ni:  0.000175415

Score:  0.928

Data Source:  BioPlex,STRINGDB

PLOD1

Tbio

Family:  Enzyme

Novelty:  0.00905345

p_int:  0.9997105

p_ni:  0.0002895

Score:  0.916

Data Source:  BioPlex,STRINGDB

COL20A1

Tdark

Novelty:  0.39788946

p_int:  0.999659907

p_ni:  0.000340093

Score:  0.918

Data Source:  BioPlex,STRINGDB

P4HA2

Tbio

Family:  Enzyme

Novelty:  0.02097718

p_int:  0.999534581

p_ni:  0.000465419

Score:  0.907

Data Source:  BioPlex,STRINGDB

C1QTNF9

Tbio

Novelty:  0.03485116

p_int:  0.999373681

p_ni:  0.000626319

Data Source:  BioPlex

C1QTNF2

Tbio

Novelty:  0.18607978

p_int:  0.999339207

p_ni:  0.000660793

Score:  0.154

Data Source:  BioPlex,STRINGDB

LAIR2

Tbio

Novelty:  0.06117644

p_int:  0.999272696

p_ni:  0.000727304

Data Source:  BioPlex

SCGB2A2

Tbio

Novelty:  0.01594053

p_int:  0.999214267

p_ni:  0.000785729

p_wrong:  4e-9

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (9)

Reactome (6)

KEGG (1)

PathwayCommons (2)

Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Collagen biosynthesis and modifying enzymes	67 targets	R-HSA-1650814
Reactome	Collagen chain trimerization	44 targets	R-HSA-8948216
Reactome	Collagen degradation	40 targets	R-HSA-1442490
Reactome	Collagen formation	90 targets	R-HSA-1474290
Reactome	Degradation of the extracellular matrix	111 targets	R-HSA-1474228

Name	Explore in Pharos	Explore in Source
Collagen biosynthesis and modifying enzymes	67 targets	R-HSA-1650814
Collagen chain trimerization	44 targets	R-HSA-8948216
Collagen degradation	40 targets	R-HSA-1442490
Collagen formation	90 targets	R-HSA-1474290
Degradation of the extracellular matrix	111 targets	R-HSA-1474228

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (5)

Components (7)

Processes (4)

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1 – 5 of 5

GO Term	Evidence	Assigned by
extracellular matrix structural constituent conferring tensile strength	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
collagen binding	Non-traceable Author Statement (NAS)	UniProtKB
extracellular matrix structural constituent	Non-traceable Author Statement (NAS)	UniProtKB
protein binding, bridging	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (7)

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1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet crit	EFO_0007985	1	1	1		60.2
platelet count	EFO_0004309	1	1	1		56.8
heel bone mineral density	EFO_0009270	3	2	3		53.1
C-reactive protein measurement	EFO_0004458	1	1	1		46.1
waist circumference	EFO_0004342	1	1	1		33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet crit	EFO_0007985	1		60.2
platelet count	EFO_0004309	1		56.8
heel bone mineral density	EFO_0009270	3		53.1
C-reactive protein measurement	EFO_0004458	1		46.1
waist circumference	EFO_0004342	1		33.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell adhesion
Collagen
Complete proteome
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Hydroxylation
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
C-reactive protein measurement
ganglion cell inner plexiform layer thickness measurement
heart rate response to exercise
heel bone mineral density
platelet count
platelet crit
waist circumference

MGI Phenotype Find Similar Targets

No Header	No Header
integument phenotype
muscle phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	collagen type XIV alpha 1 chain	VGNC:10673	464358
Mouse	collagen, type XIV, alpha 1	MGI:1341272	12818
Rat	collagen type XIV alpha 1 chain	RGD:1305806	314981
Dog	collagen type XIV alpha 1 chain	VGNC:51768	475085
Horse	collagen type XIV alpha 1 chain		100033841

Species	Name	OMA	EggNOG	Inparanoid
Chimp	collagen type XIV alpha 1 chain
Mouse	collagen, type XIV, alpha 1
Rat	collagen type XIV alpha 1 chain
Dog	collagen type XIV alpha 1 chain
Horse	collagen type XIV alpha 1 chain

Publication Statistics

PubMed Score 52.88

PubMed score by year

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PubTator Score 167.14

PubTator score by year

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Related Publications

Text Mined References (37)

GeneRif Annotations (8)

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PMID	Year	Title