Tbio COL13A1 Collagen alpha-1(XIII) chain

Protein Summary

Description

Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625). This gene encodes the alpha chain of one of the nonfibrillar collagens. The function of this gene product is not known, however, it has been detected at low levels in all connective tissue-producing cells so it may serve a general function in connective tissues. Unlike most of the collagens, which are secreted into the extracellular matrix, collagen XIII contains a transmembrane domain and the protein has been localized to the plasma membrane. The transcripts for this gene undergo complex and extensive splicing involving at least eight exons. Like other collagens, collagen XIII is a trimer; it is not known whether this trimer is composed of one or more than one alpha chain isomer. A number of alternatively spliced transcript variants have been described, but the full length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q5TAT6
• A6NFR5
• B9EGD2
• E7EWL8
• Q13992
• Q13993
• Q13994
• Q13995
• Q13996
• Q5TAT4
• Q5TAT5
• Q7KZ33
• Q7KZ49
• Q99228
• Q9NQ52

Gene Name

• COL13A1

Ensembl ID

• ENST00000354547
• ENSP00000346553
• ENSG00000197467
• ENST00000357811
• ENSP00000350463
• ENST00000398978
• ENSP00000381949
• ENST00000517713
• ENSP00000430061
• ENST00000520133
• ENSP00000430173
• ENST00000520267
• ENSP00000428057
• ENST00000522165
• ENSP00000428342

Symbol

• CMS19
• COLXIIIA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.95
gene perturbation	0.75
transcription factor binding site profile	0.67
cellular component	0.66
disease	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.22   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.22   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0